ZFIN ID: ZDB-GENE-040426-1421
Gene Name: chaperonin containing TCP1, subunit 4 (delta)
Gene Symbol: cct4    Nomenclature History

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Previous Names: zgc:65789, zgc:77192 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have ATP binding activity and unfolded protein binding activity. Involved in response to hypoxia. Predicted to localize to the chaperonin-containing T-complex. Is expressed in several structures, including head; immature eye; midbrain; muscle; and pectoral fin bud. Orthologous to human CCT4 (chaperonin containing TCP1 subunit 4).
Genome Resources: Alliance (1),  Gene:393555 (1),  Ensembl(GRCz11):ENSDARG00000013475 (2)
GENE EXPRESSION
All Expression Data: 10 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:65789]
  6 figures (11 images) from Thisse et al., 2004 [IMAGE:6907982]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
pc34 Small Deletion Exon 5 Frameshift CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-cct4 1
DISEASE ASSOCIATED WITH cct4 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH cct4 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process response to hypoxia (more)
Cellular Component cytoplasm (more)
Molecular Function ATP binding (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Conserved_site IPR002194 Chaperonin TCP-1, conserved site
Family IPR002423 Chaperonin Cpn60/TCP-1 family
Family IPR012717 T-complex protein 1, delta subunit
Family IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)
Homologous_superfamily IPR027409 GroEL-like apical domain superfamily
Homologous_superfamily IPR027410 TCP-1-like chaperonin intermediate domain superfamily
Homologous_superfamily IPR027413 GroEL-like equatorial domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA cct4-201 (1)    Ensembl 1914
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-cct4 monoclonal IgG Rabbit IHC, WB Abcam plc
2
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cct4 No data available
MARKER RELATIONSHIPS
cct4 Contained in: [Fosmid] CH1073-237G6 (1), ZFOS-663F11 (1)
cct4 Encodes: [EST] IMAGE:6907982 (1)
[cDNA] MGC:65789 (1), MGC:77192
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_200583 (1) 1940 bp
Genomic GenBank:CU693443 (1) 43828 bp
Select Tool
Polypeptide UniProtKB:Q6P123 (1) 533 aa
Sequence Information (all 17)
ORTHOLOGY for cct4 ( Chr: 1 )
CITATIONS (28)