ZFIN ID: ZDB-GENE-040426-1317
Gene Name: uncoupling protein 3
Gene Symbol: ucp3    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: ucp2l, zgc:63967

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have oxidative phosphorylation uncoupler activity. Predicted to be involved in adaptive thermogenesis; mitochondrial transmembrane transport; and response to cold. Predicted to localize to the integral component of membrane and mitochondrial membrane. Human ortholog(s) of this gene implicated in coronary restenosis; diabetic neuropathy; glucose metabolism disease (multiple); and obesity. Is expressed in several structures, including brain; eye; heart; integument; and pleuroperitoneal region. Orthologous to human UCP3 (uncoupling protein 3).
Genome Resources: Alliance (1),  Gene:794081 (1),  Ensembl(GRCz11):ENSDARG00000091209 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa41711 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ucp3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    obesity Alliance {Obesity, severe, and type II diabetes} 601665
    DISEASE ASSOCIATED WITH ucp3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process mitochondrial transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function oxidative phosphorylation uncoupler activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR002030 Mitochondrial carrier UCP-like
    Homologous_superfamily IPR023395 Mitochondrial carrier domain superfamily
    Repeat IPR018108 Mitochondrial substrate/solute carrier
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ucp3-201 (1)    Ensembl 1676
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ucp3 No data available
    MARKER RELATIONSHIPS
    ucp3 Contained in: [BAC] CH211-176G13 (1)
    ucp3 Encodes: [cDNA] MGC:63967 (1), MGC:174528 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200353 (1) 1698 nt
    Genomic GenBank:BX649477 (1) 148317 nt
    Select Tool
    Polypeptide UniProtKB:A8KC25 (1) 309 aa
    Sequence Information (all 16)
    ORTHOLOGY for ucp3 ( Chr: 10 )
    CITATIONS (25)