ZFIN ID: ZDB-GENE-040426-1221
Gene Name: heat shock cognate 70
Gene Symbol: hsc70    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: zgc:63663

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have several functions, including ATP binding activity; misfolded protein binding activity; and protein folding chaperone. Predicted to be involved in several processes, including cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Predicted to localize to the cytosol; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune hypersensitivity disease (multiple); cystic fibrosis; schizophrenia (multiple); and toxic shock syndrome. Is expressed in myotome. Orthologous to several human genes including HSPA1L (heat shock protein family A (Hsp70) member 1 like); HSPA1A (heat shock protein family A (Hsp70) member 1A); and HSPA1B (heat shock protein family A (Hsp70) member 1B).
Genome Resources: Alliance (1),  Gene:393586 (1),  Ensembl(GRCz11):ENSDARG00000012381 (2)
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Directly Submitted Expression Data: 6 figures (4 images) from Thisse et al., 2004 [MGC:63663]
Wild-type Stages, Structures: Pharyngula:Prim-15 (30.0h-36.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH hsc70 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH hsc70 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cellular response to unfolded protein (more)
Cellular Component cytoplasm (more)
Molecular Function ATP binding (more)
GO Terms (all 17)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Family IPR013126 Heat shock protein 70 family
Conserved_site IPR018181 Heat shock protein 70, conserved site
Homologous_superfamily IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
Homologous_superfamily IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA hsc70-201 (1)    Ensembl 2469
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM hsc70
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(CMV:EGFP,hsc70:Cca.Ckm3) hsc70 EGFP Cyprinus carpioDanio rerio 1 2
MARKER RELATIONSHIPS
hsc70 Contained in: [BAC] DKEY-238D18 (1) (order this)
hsc70 Encodes: [cDNA] MGC:63663 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_200614 (1) 2476 bp
Genomic GenBank:CR944667 (1) 209310 bp Blast at MegaBLAST
Polypeptide UniProtKB:Q6PGX4 (1) 647 aa
Sequence Information (all 8)
ORTHOLOGY for hsc70 ( Chr: 15 )
CITATIONS (23)