ZFIN ID: ZDB-GENE-040426-1221 |
Gene Name: | heat shock cognate 70 | ||||||
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Gene Symbol: | hsc70 Nomenclature History | ||||||
Previous Name: | zgc:63663 | ||||||
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Gene Type: | protein_coding_gene | ||||||
Location: | Chr: 15 Mapping Details/Browsers | ||||||
Description: | Predicted to have several functions, including ATP binding activity; misfolded protein binding activity; and protein folding chaperone. Predicted to be involved in several processes, including cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Predicted to localize to the cytosol; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune hypersensitivity disease (multiple); cystic fibrosis; schizophrenia (multiple); and toxic shock syndrome. Is expressed in myotome. Orthologous to several human genes including HSPA1L (heat shock protein family A (Hsp70) member 1 like); HSPA1A (heat shock protein family A (Hsp70) member 1A); and HSPA1B (heat shock protein family A (Hsp70) member 1B). | ||||||
Genome Resources: | Alliance (1), Gene:393586 (1), Ensembl(GRCz11):ENSDARG00000012381 (2) |
All Expression Data: | 7 figures from 2 publications |
Directly Submitted Expression Data: | 6 figures (4 images) from Thisse et al., 2004 [MGC:63663] |
Wild-type Stages, Structures: | Pharyngula:Prim-15 (30.0h-36.0h) to Adult (90d-730d, breeding adult) |
Curated Microarray Expression: | GEO (1) |
Ontology | GO Term |
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Biological Process | cellular response to unfolded protein (more) |
Cellular Component | cytoplasm (more) |
Molecular Function | ATP binding (more) |
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Type | Name | Length (nt) | Analysis | |
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mRNA |
hsc70-201
(1)
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2469 |
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Browsers: UCSC, NCBI, Ensembl, ZFIN |
Construct | Regulatory Regions | Coding Sequences | Species | Tg Lines | Publications |
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Tg(CMV:EGFP,hsc70:Cca.Ckm3) | hsc70 | EGFP | Cyprinus carpio, Danio rerio | 1 | 2 |
hsc70 Contained in: | [BAC] DKEY-238D18 (1) (order this) |
hsc70 Encodes: | [cDNA] MGC:63663 (1) (order this) |
Type | Accession # | Length (bp/aa) | Analysis |
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RNA | RefSeq:NM_200614 (1) | 2476 bp |
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Genomic | GenBank:CR944667 (1) | 209310 bp | Blast at MegaBLAST |
Polypeptide | UniProtKB:Q6PGX4 (1) | 647 aa |
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Sequence Clusters | UniGene:85225 (1) |