ZFIN ID: ZDB-GENE-040426-1221

Gene Name:	heat shock cognate 70
Gene Symbol:	hsc70    Nomenclature History	{{control.fieldName}} Edit ID: {{control.nomenID}} {{control.fieldName}}: Reason: Comments: {{control.comments}} Cancel Update Attributions {{pub.zdbID}} Add
Previous Name:	zgc:63663
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Gene Type:	protein_coding_gene
Location:	Chr: 15 Mapping Details/Browsers
Description:	Predicted to have several functions, including ATP binding activity; misfolded protein binding activity; and protein folding chaperone. Predicted to be involved in several processes, including cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Predicted to localize to the cytosol; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune hypersensitivity disease (multiple); cystic fibrosis; schizophrenia (multiple); and toxic shock syndrome. Is expressed in myotome. Orthologous to several human genes including HSPA1L (heat shock protein family A (Hsp70) member 1 like); HSPA1A (heat shock protein family A (Hsp70) member 1A); and HSPA1B (heat shock protein family A (Hsp70) member 1B).
Genome Resources:	Alliance (1),  Gene:393586 (1),  Ensembl(GRCz11):ENSDARG00000012381 (2)

PROTEIN FAMILIES, DOMAINS AND SITES

Type	InterPro ID	Name
Family	IPR013126	Heat shock protein 70 family
Conserved_site	IPR018181	Heat shock protein 70, conserved site
Homologous_superfamily	IPR029047	Heat shock protein 70kD, peptide-binding domain superfamily
Homologous_superfamily	IPR029048	Heat shock protein 70kD, C-terminal domain superfamily