ZFIN ID: ZDB-GENE-040426-1178
Gene Name: protein kinase C, beta b
Gene Symbol: prkcbb    Nomenclature History

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Previous Names: prkcb1, zgc:63591 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have several functions, including androgen receptor binding activity; histone kinase activity (H3-T6 specific); and nuclear receptor transcription coactivator activity. Involved in blood coagulation and embryonic hemopoiesis. Predicted to localize to nucleus. Is expressed in brain; retinal neural layer; and somite border. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta).
Genome Resources: Alliance (1),  Gene:393953 (1),  Ensembl(GRCz11):ENSDARG00000022254 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la015188Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la015189Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la024154Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028908Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13860 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20072 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-prkcbb N/A 1
    MO2-prkcbb N/A 1
    MO3-prkcbb N/A 1
    DISEASE ASSOCIATED WITH prkcbb HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH prkcbb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood coagulation (more)
    Cellular Component nucleus (more)
    Molecular Function androgen receptor binding (more)
    GO Terms (all 32)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA prkcbb-201 (1)    Ensembl 4340
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-prkcb1 monoclonal IgG1 Mouse IHC Santa Cruz Biotechnology, Inc.
    4
    Ab2-prkcb1 polyclonal IgG Rabbit IHC Santa Cruz Biotechnology, Inc.
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prkcbb No data available
    MARKER RELATIONSHIPS
    prkcbb Contained in: [BAC] CH73-296E5 (1), CH211-112M13 (1), CH211-208P14 (1), DKEY-15H19 (1) (order this)
    prkcbb Encodes: [cDNA] MGC:63591 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200978 (1) 4369 nt
    Genomic GenBank:BX664600 (1) 167489 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QMW2 (1) 670 aa
    Sequence Information (all 21)
    ORTHOLOGY for prkcbb ( Chr: 3 )
    CITATIONS (44)