ZFIN ID: ZDB-GENE-040426-1172
Gene Name: solute carrier family 25 member 1a
Gene Symbol: slc25a1a    Nomenclature History

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Previous Names: cic (1), slc25a1, zgc:63578 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Involved in regulation of mitochondrion organization. Predicted to localize to integral component of membrane and mitochondrial inner membrane. Human ortholog(s) of this gene implicated in 2-hydroxyglutaric aciduria; combined D-2- and L-2-hydroxyglutaric aciduria; and congenital myasthenic syndrome. Orthologous to human SLC25A1 (solute carrier family 25 member 1).
Genome Resources: Alliance (1),  Gene:393579 (1),  Ensembl(GRCz11):ENSDARG00000057110 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:63578]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7157930]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13471 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15431 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-slc25a1a N/A 1
    DISEASE ASSOCIATED WITH slc25a1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    combined D-2- and L-2-hydroxyglutaric aciduria Alliance Combined D-2- and L-2-hydroxyglutaric aciduria 615182
    Myasthenic syndrome, congenital, 23, presynaptic 618197
    DISEASE ASSOCIATED WITH slc25a1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process neuromuscular junction development (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA slc25a1a-201 (1)    Ensembl 1909
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slc25a1a No data available
    MARKER RELATIONSHIPS
    slc25a1a Contained in: [BAC] DKEY-175G6 (1) (order this)
    slc25a1a Encodes: [EST] IMAGE:7157930 (1)
    [cDNA] MGC:63578 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200607 (1) 1926 nt
    Genomic GenBank:CR926463 (1) 167657 nt
    Select Tool
    Polypeptide UniProtKB:Q6PGY3 (1) 359 aa
    Sequence Information (all 10)
    ORTHOLOGY for slc25a1a ( Chr: 10 )
    CITATIONS (27)