Gene

irf6

ID
ZDB-GENE-040426-1137
Name
interferon regulatory factor 6
Symbol
irf6 Nomenclature History
Previous Names
  • zgc:63500 (1)
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in embryonic neurocranium morphogenesis and epithelium development. Predicted to localize to nucleus. Is expressed in several structures, including blastoderm; digestive system; forerunner cell group; head; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including Van der Woude syndrome; cleft lip; orofacial cleft 6; popliteal pterygium syndrome; and syndactyly. Orthologous to human IRF6 (interferon regulatory factor 6).
Genome Resources
Note
None
Expression
All Expression Data
7 figures from 5 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Li et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With irf6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
orofacial cleft 6 Alliance {Orofacial cleft 6} 608864
popliteal pterygium syndrome Alliance Popliteal pterygium syndrome 1 119500
Van der Woude syndrome Alliance van der Woude syndrome 119300
Associated With irf6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019817 Interferon regulatory factor, conserved site
Domain IPR001346 Interferon regulatory factor DNA-binding domain
Domain IPR019471 Interferon regulatory factor-3
Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
Homologous_superfamily IPR017855 SMAD-like domain superfamily
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Interferon regulatory factor-3 Interferon regulatory factor, conserved site Interferon regulatory factor DNA-binding domain SMAD/FHA domain superfamily SMAD-like domain superfamily Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:Q6PGZ7 492
UniProtKB:A0A0R4IQV7 161
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-irf6 polyclonal Rabbit
  • IHC
1
Ab2-irf6 polyclonal Rabbit
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations