Gene

irf6

ID
ZDB-GENE-040426-1137
Name
interferon regulatory factor 6
Symbol
irf6 Nomenclature History
Previous Names
  • zgc:63500 (1)
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in embryonic neurocranium morphogenesis and epithelium development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including Van der Woude syndrome; cleft lip; orofacial cleft 6; popliteal pterygium syndrome; and syndactyly. Is expressed in several structures, including blastoderm; digestive system; forerunner cell group; head; and sensory system. Orthologous to human IRF6 (interferon regulatory factor 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With irf6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
orofacial cleft 6 Alliance {Orofacial cleft 6} 608864
popliteal pterygium syndrome Alliance Popliteal pterygium syndrome 1 119500
Van der Woude syndrome Alliance van der Woude syndrome 1 119300
Associated With irf6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019817 Interferon regulatory factor, conserved site
Domain IPR001346 Interferon regulatory factor DNA-binding domain
Domain IPR019471 Interferon regulatory factor-3
Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
Homologous_superfamily IPR017855 SMAD-like domain superfamily
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Interferon regulatory factor-3 Interferon regulatory factor, conserved site Interferon regulatory factor DNA-binding domain SMAD/FHA domain superfamily SMAD-like domain superfamily Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:A0A0R4IQV7 161
UniProtKB:Q6PGZ7 492
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-irf6 polyclonal Rabbit
  • IHC
1
Ab2-irf6 polyclonal Rabbit
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations