Gene

usf1

ID

ZDB-GENE-040426-1072

Name

upstream transcription factor 1

Symbol

usf1 Nomenclature History

Previous Names

zgc:56547

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Human ortholog(s) of this gene implicated in cardiovascular system disease and type 2 diabetes mellitus. Orthologous to human USF1 (upstream transcription factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UCSC scRNA-seq

Thisse Expression Data

MGC:56547 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With usf1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Hyperlipidemia, familial combined, susceptibility to}	602491

Associated With usf1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Helix-loop-helix DNA-binding domain superfamily	Myc-type, basic helix-loop-helix (bHLH) domain
UniProtKB:E9QFN2 InterPro	205
UniProtKB:F1QUA1 InterPro	309
UniProtKB:Q7ZWC6 InterPro	309
UniProtKB:E9QEC7 InterPro	213
UniProtKB:E9QBT6 InterPro	237
UniProtKB:F1QQW3 InterPro	230
UniProtKB:E9QIH8 InterPro	228
UniProtKB:E9QHY9 InterPro	90
UniProtKB:E9QDM4 InterPro	156
UniProtKB:E9QBR1 InterPro	266
UniProtKB:E9QFD0 InterPro	224
UniProtKB:A0A0R4IXK2 InterPro	299

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
aberrant processed transcript	usf1-207 (1) Ensembl	1450 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	usf1-201 (1) Ensembl	1492 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	usf1-202 (1) Ensembl	710 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	usf1-203 (1) Ensembl	402 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	usf1-204 (1) Ensembl	931 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	usf1-205 (1) Ensembl	579 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	usf1-206 (1) Ensembl	832 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	usf1-208 (1) Ensembl	765 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	usf1-209 (1) Ensembl	805 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	usf1-210 (1) Ensembl	838 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations