ZFIN ID: ZDB-GENE-040426-1039
Gene Name: eukaryotic translation initiation factor 2B, subunit 3 gamma
Gene Symbol: eif2b3    Nomenclature History

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Previous Name: zgc:56473 (1)

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Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have guanyl-nucleotide exchange factor activity and translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to localize to eukaryotic translation initiation factor 2B complex and guanyl-nucleotide exchange factor complex. Is expressed in eye and gut. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma).
Genome Resources: Alliance (1),  Gene:394049 (1),  Ensembl(GRCz11):ENSDARG00000018106 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6909645]
  4 figures (12 images) from Rauch et al., 2003 [fq32g07]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa32957 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH eif2b3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    leukoencephalopathy with vanishing white matter Alliance Leukoencephalopathy with vanishing white matter 603896
    DISEASE ASSOCIATED WITH eif2b3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process biosynthetic process (more)
    Cellular Component eukaryotic translation initiation factor 2B complex (more)
    Molecular Function nucleotidyltransferase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA eif2b3-201 (1)    Ensembl 1737
    eif2b3-202 (1)    Ensembl 698
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM eif2b3 No data available
    MARKER RELATIONSHIPS
    eif2b3 Contained in: [BAC] CH211-226H23 (1)
    eif2b3 Encodes: [EST] fq32g07 (1) (order this), IMAGE:6909645 (1)
    [cDNA] MGC:56473 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201074 (1) 1755 nt
    Genomic GenBank:BX649493 (1) 175551 nt
    Select Tool
    Polypeptide UniProtKB:Q7ZTY5 (1) 453 aa
    Sequence Information (all 14)
    ORTHOLOGY for eif2b3 ( Chr: 2 )
    CITATIONS (24)