ZFIN ID: ZDB-GENE-040426-1036
Gene Name: dystrobrevin binding protein 1a
Gene Symbol: dtnbp1a    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: dtnbp1, hps7 (1), zgc:56462 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to be involved in several processes, including anterograde synaptic vesicle transport; platelet dense granule organization; and regulation of synaptic vesicle exocytosis. Predicted to localize to several cellular components, including BLOC-1 complex; neuron projection; and synaptic vesicle membrane. Is expressed in several structures, including epidermis; neural crest; periderm; pigment cell; and retina. Used to study Hermansky-Pudlak syndrome. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome 7 and schizophrenia. Orthologous to human DTNBP1 (dystrobrevin binding protein 1).
Genome Resources: Alliance (1),  Gene:394109 (1),  Ensembl(GRCz11):ENSDARG00000055115 (2)
GENE EXPRESSION
All Expression Data: 7 figures from 3 publications
Directly Submitted Expression Data: 5 figures (13 images) from Thisse et al., 2004 [MGC:56462]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb819 Small Deletion Unknown Unknown CRISPR
sa36137 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-dtnbp1a 2
    DISEASE ASSOCIATED WITH dtnbp1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Hermansky-Pudlak syndrome 7 Alliance Hermansky-Pudlak syndrome 7 614076
    DISEASE ASSOCIATED WITH dtnbp1a VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Hermansky-Pudlak syndrome dtnbp1aihb819/ihb819 standard conditions Chen et al., 2018
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterograde axonal transport (more)
    Cellular Component BLOC-1 complex (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dtnbp1a-201 (1)    Ensembl 2027
    dtnbp1a-203 (1)    Ensembl 885
    dtnbp1a-205 (1)    Ensembl 880
    dtnbp1a-207 (1)    Ensembl 741
    ncRNA dtnbp1a-003 (1)    Ensembl 804
    dtnbp1a-004 (1)    Ensembl 785
    dtnbp1a-005 (1)    Ensembl 538
    dtnbp1a-008 (1)    Ensembl 421
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dtnbp1a No data available
    MARKER RELATIONSHIPS
    dtnbp1a Contained in: [BAC] DKEY-25O19 (1) (order this)
    dtnbp1a Encodes: [cDNA] MGC:56462 (1), MGC:174073 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201134 (1) 1794 nt
    Genomic GenBank:CR391941 (1) 187002 nt
    Select Tool
    Polypeptide UniProtKB:A7YYI2 (1) 362 aa
    Sequence Information (all 37)
    ORTHOLOGY for dtnbp1a ( Chr: 16 )
    CITATIONS (27)