ZFIN ID: ZDB-GENE-040420-1
Gene Name: alkaline phosphatase, liver/bone/kidney
Gene Symbol: alpl

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Previous Names: alp (1), zgc:56672

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Location: Chr: 11 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 19 figures from 12 publications
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2004 [MGC:56672]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
  alar plate midbrain region, anatomical structure, axial vasculature, cerebellum (all 26) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011993Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41854 Point Mutation Unknown Premature Stop ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH alpl HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    hypophosphatasia Hypophosphatasia, adult 146300
    Hypophosphatasia, childhood 241510
    Hypophosphatasia, infantile 241500
    Odontohypophosphatasia 146300
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to mechanical stimulus (more)
    Cellular Component integral component of membrane (more)
    Molecular Function alkaline phosphatase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001952 (1)
  • InterPro:IPR017849 (1)
  • InterPro:IPR017850 (1)
  • InterPro:IPR018299 (1)
  • PROSITE:PS00123 (1)
  • Pfam:PF00245 (1)
  • EC:3.1.3.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA alpl-001 (1) 1871
    alpl-002 (1) 812
    alpl-003 (1) 640
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM alpl
    Tg(alpl:mCherry)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    alplContained in: [BAC] CH211-220M17 (1) (order this)
    alplEncodes: [cDNA] MGC:56672 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_201007 (1) 3712bp
    Genomic GenBank:BX248318 (1) 194209bp
    Select Tool
    Polypeptide UniProtKB:F1Q5B5 (1) 561aa
    Sequence Clusters UniGene:116988 (1)
    Sequence Information (all 23)
    OTHER alpl GENE PAGES
  • Gene:393982 (1)
  • VEGA:OTTDARG00000020427 (1)
  • Ensembl(GRCz10):ENSDARG00000015546 (1)
  • ORTHOLOGY for alpl (Chr: 11)
    Species Symbol Chromosome Accession # Evidence
    Human ALPL 1
  • Gene:249
  • OMIM:171760
  • HGNC:438
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (2)
    Mouse Alpl 4
  • MGI:87983
  • Gene:11647
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (39)