Gene

alpl

ID
ZDB-GENE-040420-1
Name
alkaline phosphatase, biomineralization associated
Symbol
alpl Nomenclature History
Previous Names
  • alp (1)
  • zgc:56672
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have alkaline phosphatase activity. Involved in response to mechanical stimulus. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; infantile hypophosphatasia; and uremia. Is expressed in several structures, including anterior neural keel; bone element; central nervous system; gut; and vasculature. Orthologous to human ALPL (alkaline phosphatase, biomineralization associated).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
31 figures from 20 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With alpl Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
adult hypophosphatasia Alliance Hypophosphatasia, adult 146300
adult hypophosphatasia Alliance Odontohypophosphatasia 146300
childhood hypophosphatasia Alliance Hypophosphatasia, childhood 241510
infantile hypophosphatasia Alliance Hypophosphatasia, infantile 241500
Associated With alpl Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018299 Alkaline phosphatase, active site
Family IPR001952 Alkaline phosphatase
Homologous_superfamily IPR017850 Alkaline-phosphatase-like, core domain superfamily
Domain Details Per Protein
Protein Length Alkaline phosphatase Alkaline phosphatase, active site Alkaline-phosphatase-like, core domain superfamily
UniProtKB:Q8AXY4 293
UniProtKB:F1Q5B5 561
UniProtKB:E9QHW5 129
UniProtKB:E9QCQ8 229
UniProtKB:K4KG66 561
UniProtKB:Q7ZTV9 451
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations