ZFIN ID: ZDB-GENE-040420-1
Gene Name: alkaline phosphatase, biomineralization associated
Gene Symbol: alpl    Nomenclature History

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Previous Names: alp (1), zgc:56672

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have alkaline phosphatase activity. Involved in response to mechanical stimulus. Predicted to localize to plasma membrane. Is expressed in several structures, including anterior neural keel; bone element; central nervous system; gut; and vasculature. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; infantile hypophosphatasia; and uremia. Orthologous to human ALPL (alkaline phosphatase, biomineralization associated).
Genome Resources: Alliance (1),  Gene:393982 (1),  Ensembl(GRCz11):ENSDARG00000015546 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011993Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41854 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH alpl HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    adult hypophosphatasia Alliance Hypophosphatasia, adult 146300
    Odontohypophosphatasia 146300
    childhood hypophosphatasia Alliance Hypophosphatasia, childhood 241510
    infantile hypophosphatasia Alliance Hypophosphatasia, infantile 241500
    DISEASE ASSOCIATED WITH alpl VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to mechanical stimulus (more)
    Cellular Component integral component of membrane (more)
    Molecular Function alkaline phosphatase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA alpl-201 (1)    Ensembl 640
    alpl-202 (1)    Ensembl 1871
    alpl-203 (1)    Ensembl 812
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM alpl
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(alpl:mCherry) alpl mCherry Danio rerio 1 5
    MARKER RELATIONSHIPS
    alpl Contained in: [BAC] CH211-220M17 (1)
    alpl Encodes: [cDNA] MGC:56672 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201007 (1) 1739 nt
    Genomic GenBank:BX248318 (1) 194209 nt
    Select Tool
    Polypeptide UniProtKB:F1Q5B5 (1) 561 aa
    Sequence Information (all 22)
    ORTHOLOGY for alpl ( Chr: 11 )
    CITATIONS (65)