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ZIRC
ZFIN ID: ZDB-GENE-040409-1
Gene Name: motor neuron and pancreas homeobox 1
Gene Symbol: mnx1    Nomenclature History

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Previous Names: Hb9 (1), hlxb9 (1), zgc:112174

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity. Involved in spinal cord motor neuron cell fate specification and type B pancreatic cell differentiation. Predicted to localize to the nucleus. Is expressed in several structures, including central nervous system; endoderm; mesoderm; neurons; and pancreatic system. Orthologous to human MNX1 (motor neuron and pancreas homeobox 1).
Genome Resources: Alliance (1),  Gene:405399 (1),  Ensembl(GRCz11):ENSDARG00000035984 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-mnx1 N/A 2
MO2-mnx1 N/A 7
MO3-mnx1 N/A 1
MO4-mnx1 N/A 1
MO5-mnx1 N/A 3
DISEASE ASSOCIATED WITH mnx1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Currarino syndrome 176450
DISEASE ASSOCIATED WITH mnx1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process endocrine pancreas development (more)
Cellular Component nucleus (more)
Molecular Function DNA-binding transcription factor activity (more)
GO Terms (all 9)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA mnx1-201 (1)    Ensembl 1469
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
CONSTRUCTS WITH SEQUENCES FROM mnx1
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(-2.6mnx1:EGFP) mnx1 EGFP Danio rerio 1 2
Tg(-2.6mnx1:GFP) mnx1 GFP Danio rerio 1 6
Tg(-3.0mnx1:mTagBFP) mnx1 TagBFP Danio rerio 1 8
tg(-3mnx1:egfp-hsa.tardbp) mnx1 EGFP Danio rerioHomo sapiens 1 2
Tg(-3mnx1:KALTA4-4xUAS-E1B-Hsa.HIST2H2BE-mCerulean3-P2A-mKOFP2-CAAX) mnx1 2ACAAXCeruleanE1BKALTA4mKOFP2UAS Danio rerio 1 2
Tg(-3mnx1:MLS-KillerRed) mnx1 KillerRedMLS Danio rerio 1 2
Tg(2xNRSE-mnx1-Mmu.Fos:KALTA4,5xUAS-E1B:GAP-YFP-2A-NTR) E1Bmnx1NRSEUAS 2AGAPKALTA4NTRYFP Danio rerioMus musculus 1 1
Tg(2xNRSE-mnx1-Mmu.Fos:KALTA4,5xUAS-E1B:GAP-YFP-2A-NTR_T41Q_N71S_F124T) E1Bmnx1NRSEUAS 2AGAPKALTA4NTRYFP Danio rerioMus musculus 1 1
Tg(3xmnx1:GAL4-VP16) mnx1 GAL4VP16 Danio rerio 2 8
Tg(hsp70l:mnx1,hsp70l:YFP) hsp70l mnx1YFP Danio rerio 1 1
Tg(hsp70l:mnx1-VP16,hsp70l:YFP) hsp70l mnx1VP16YFP Danio rerio 1 1
Tg(mnx1-0.6hsp70l:RFP-Hsa.SMN1) hsp70lmnx1 RFP Danio rerioHomo sapiens 1 4
Tg(mnx1-1.5hsp70l:GFP-Hsa.SNRPB) hsp70lmnx1 GFP Danio rerioHomo sapiens 1 3
Tg(mnx1-1.5hsp70l:mCherry-elavl4) hsp70lmnx1 elavl4mCherry Danio rerio 1 1
Tg(mnx1-1.5hsp70l:RFP-Hsa.SMN1) hsp70lmnx1 RFP Danio rerioHomo sapiens 2 3
Tg(mnx1-1.5hsp70l:RFP-Hsa.SMN1_E134K) hsp70lmnx1 RFP Danio rerioHomo sapiens 1 1
Tg(mnx1-1.5hsp70l:RFP-Hsa.SMN1_Q282A) hsp70lmnx1 RFP Danio rerioHomo sapiens 1 1
Tg(mnx1-hsp70l:EGFP) hsp70lmnx1 EGFP Danio rerio 1 14
Tg(mnx1-hsp70l:Hsa.PLS3,hsp70l:EGFP) hsp70lmnx1 EGFP Danio rerioHomo sapiens 1 3
Tg(mnx1:D3cpv) mnx1 D3cpv Danio rerio 1 2
Tg(mnx1:GAL4) mnx1 GAL4 Danio rerio 1 7
Tg(mnx1:GAL4-VP16) mnx1 GAL4VP16 Danio rerio 1 6
tg(mnx1:gal4-vp16,uas:egfp-caax) mnx1UAS CAAXEGFPGAL4VP16 Danio rerio 1 1
Tg(mnx1:GCaMP5G) mnx1 GCaMP Danio rerio 1 2
Tg(mnx1:GFP) mnx1 GFP Danio rerio 1 114
Tg(mnx1:h2az2a-TagRFP) mnx1 h2az2aTagRFP Danio rerio 1 2
Tg(mnx1:Hsa.PLS3,hsp70l:EGFP) hsp70lmnx1 EGFP Danio rerioHomo sapiens 1 3
Tg(mnx1:Hsa.SMN1,mnx1:mCherry) mnx1 mCherry Danio rerioHomo sapiens 1 3
Tg(mnx1:KikGR) mnx1 KikGR Danio rerio 1 2
Tg(mnx1:lrp4-GFP) mnx1 GFPlrp4 Danio rerio 1 2
Tg(mnx1:mCherry) mnx1 mCherry Danio rerio 1 3
Tg(mnx1:mCherry-smn1) mnx1 mCherrysmn1 Danio rerio 1 1
Tg(mnx1:mGFP) mnx1 GFP Danio rerio 1 11
Tg(mnx1:MITO-Kaede) mnx1 KaedeMITO Danio rerio 1 1
Tg(mnx1:mK0FP2-CAAX) mnx1 CAAXmKOFP2 Danio rerio 1 5
Tg(mnx1:MKATE2,mnx1:Mmu.Cd8-MKATE2) mnx1 MKATE2 Danio rerioMus musculus 1 2
Tg(mnx1:Mmu.Cd8-GFP,mnx1:Mmu.Cd8-GFP) mnx1 GFP Danio rerioMus musculus 1 2
Tg(mnx1:Mmu.Wlds-GFP) mnx1 GFP Danio rerioMus musculus 1 4
Tg(mnx1:QF) mnx1 QF Danio rerio 1 2
Tg(mnx1:TagRFP) mnx1 TagRFP Danio rerio 1 12
Tg(Xla.Cryga:RFP,mnx1:Venus) mnx1 RFPVenus Danio rerioXenopus laevis 1 2
Tg1(-3.1mnx1:GFP) mnx1 GFP Danio rerio 1 4
Tg1(mnx1-hsp70l:GFP) hsp70lmnx1 GFP Danio rerio 1 3
Tg1(mnx1:GAL4) mnx1 GAL4 Danio rerio 1 5
Tg2(-3.1mnx1:GFP) mnx1 GFP Danio rerio 1 2
Tg2(mnx1-hsp70l:GFP) hsp70lmnx1 GFP Danio rerio 1 3
Tg2(mnx1:GAL4) mnx1 GAL4 Danio rerio 1 1
tg2(mnx1:gal4-vp16) mnx1 GAL4VP16 Danio rerio 1 1
tg2(mnx1:gfp) mnx1 GFP Danio rerio 1 1
tg3(mnx1:gal4) mnx1 GAL4 Danio rerio 1 1
MARKER RELATIONSHIPS
mnx1 Contained in: [BAC] CH211-266O5 (1) (order this)
mnx1 Encodes: [cDNA] MGC:112174 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001009885 (1) 1486 bp
Genomic GenBank:BX247878 (1) 190715 bp
Select Tool
Polypeptide UniProtKB:Q6SYZ1 (1) 311 aa
Sequence Clusters UniGene:91917 (1)
Sequence Information (all 15)
ORTHOLOGY for mnx1 ( Chr: 7 )
CITATIONS (93)