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ZIRC
ZFIN ID: ZDB-GENE-040319-1
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Gene Name: amyloid beta (A4) precursor-like protein 1
Gene Symbol: aplp1    Nomenclature History

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Previous Names: aplp, im:7153266, wu:fj55h01

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have heparin binding activity and transition metal ion binding activity. Predicted to localize to the integral component of membrane. Is expressed in central nervous system; cranial ganglion; neurons; retina; and retinal ganglion cell layer. Orthologous to human APLP1 (amyloid beta precursor like protein 1).
Genome Resources: Alliance (1),  Gene:404233 (1),  Ensembl(GRCz11):ENSDARG00000098368 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2004 [IMAGE:7153266]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa24738 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH aplp1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH aplp1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component integral component of membrane (more)
    Molecular Function heparin binding (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR008154 (1)
  • InterPro:IPR008155 (1)
  • InterPro:IPR011178 (1)
  • InterPro:IPR011993 (1)
  • InterPro:IPR015849 (1)
  • InterPro:IPR019543 (1)
  • InterPro:IPR019744 (1)
  • InterPro:IPR019745 (1)
  • InterPro:IPR024329 (1)
  • InterPro:IPR036176 (1)
  • InterPro:IPR036454 (1)
  • InterPro:IPR036669 (1)
  • PROSITE:PS00319 (1)
  • PROSITE:PS00320 (1)
  • Pfam:PF02177 (1)
  • Pfam:PF10515 (1)
  • Pfam:PF12924 (1)
  • Pfam:PF12925 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA aplp1-202 (1)    Ensembl 5439
    Select Tool
    Browsers: NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM aplp1 No data available
    MARKER RELATIONSHIPS
    aplp1 Contained in: [BAC] CH211-147F13 (1) (order this)
    aplp1 Encodes: [EST] fj55h01 (1), IMAGE:7153266 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001342885 (1) 5661 bp
    Select Tool
    Genomic GenBank:CR848749 (1) 161648 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IXG2 (1) 723 aa
    Select Tool
    Sequence Clusters UniGene:155640 (1)
    Sequence Information (all 31)
    ORTHOLOGY for aplp1 ( Chr: 15 )
    CITATIONS (18)