ZFIN ID: ZDB-GENE-040308-1
Gene Name: tnf receptor-associated factor 4a
Gene Symbol: traf4a    Nomenclature History

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Previous Name: traf4l

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have thioesterase binding activity; tumor necrosis factor receptor binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in positive regulation of JNK cascade. Predicted to localize to the cytoplasm and protein-containing complex. Is expressed in several structures, including axial blood vessel; digestive system; immature eye; mesoderm; and nervous system. Orthologous to human TRAF4 (TNF receptor associated factor 4).
Genome Resources: Alliance (1),  Gene:404045 (1),  Ensembl(GRCz11):ENSDARG00000003963 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ca301 Small Deletion Unknown Unknown CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-traf4a 2
MO1-traf4a N/A 1
MO2-traf4a N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH traf4a HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH traf4a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process activation of NF-kappaB-inducing kinase activity (more)
Cellular Component cytoplasm (more)
Molecular Function metal ion binding (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Conserved_site IPR017907 Zinc finger, RING-type, conserved site
Domain IPR001293 Zinc finger, TRAF-type
Domain IPR001841 Zinc finger, RING-type
Domain IPR002083 MATH/TRAF domain
Domain IPR037307 TNF receptor-associated factor 4, MATH domain
Family IPR027138 TNF receptor-associated factor 4
Homologous_superfamily IPR008974 TRAF-like
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA traf4a-201 (1)    Ensembl 3072
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM traf4a No data available
MARKER RELATIONSHIPS
traf4a Contained in: [BAC] CH211-187B9 (1), DKEY-81N5 (1) (order this)
traf4a Encodes: [EST] eu286 (1)
[cDNA] MGC:77418 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_205762 (1) 3090 nt
Genomic GenBank:CR392353 (1) 183599 nt
Select Tool
Polypeptide UniProtKB:Q7T1K2 (1) 470 aa
Sequence Information (all 14)
ORTHOLOGY for traf4a ( Chr: 15 )
CITATIONS (28)