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ZIRC
ZFIN ID: ZDB-GENE-040220-1
Gene Name: toll-like receptor 1
Gene Symbol: tlr1    Nomenclature History

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Previous Names: tlr6 (1), TIR1.2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have transmembrane signaling receptor activity. Predicted to be involved in inflammatory response and toll-like receptor signaling pathway. Predicted to localize to the integral component of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; aspergillosis; leprosy; pyelonephritis; and rhinitis. Orthologous to several human genes including TLR1 (toll like receptor 1).
Genome Resources: Alliance (1),  Gene:403127 (1),  Ensembl(GRCz11):ENSDARG00000100649 (1)
GENE EXPRESSION
All Expression Data: 6 figures from 4 publications
Wild-type Stages, Structures: Blastula:Dome (4.33h-4.66h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa35615 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tlr1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Leprosy, protection against} 613223
    {Leprosy, susceptibility to, 5} 613223
    DISEASE ASSOCIATED WITH tlr1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process immune system process (more)
    Cellular Component integral component of membrane (more)
    Molecular Function transmembrane signaling receptor activity (more)
    GO Terms (all 13)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tlr1-201 (1)    Ensembl 1702
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tlr1 No data available
    MARKER RELATIONSHIPS
    tlr1 Contained in: [Fosmid] ZFOS-741A10 (1)
    tlr1 Encodes: [cDNA] MGC:194575 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001130593 (1) 2517 bp
    Genomic GenBank:CU856343 (1) 38236 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IW15 (1) 795 aa
    Sequence Clusters UniGene:160679 (1)
    Sequence Information (all 16)
    ORTHOLOGY for tlr1 ( Chr: 14 )
    CITATIONS (43)