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General Information
ZIRC
ZFIN ID: ZDB-GENE-040219-8
Gene Name: toll-like receptor 4b, duplicate a
Gene Symbol: tlr4ba    Nomenclature History

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Previous Names: TIR4.1 (1), tlr4a (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to be involved in inflammatory response and toll-like receptor signaling pathway. Localizes to the protein-containing complex. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetes mellitus (multiple); eye disease (multiple); lung disease (multiple); and vasculitis (multiple). Is expressed in several structures, including blood; heart; integument; liver; and pleuroperitoneal region. Orthologous to human TLR4 (toll like receptor 4).
Genome Resources: Alliance (1),  Gene:403131 (1),  Ensembl(GRCz11):ENSDARG00000019742 (1)
GENE EXPRESSION
All Expression Data: 9 figures from 6 publications
Wild-type Stages, Structures: Blastula:Dome (4.33h-4.66h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh306 Point Mutation Unknown Unknown ENU
sa15344 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22268 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tlr4ba_unrecovered Point Mutation Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tlr4ba N/A 1
    MO2-tlr4ba N/A 2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tlr4ba HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tlr4ba VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process signal transduction (more)
    Cellular Component protein-containing complex (more)
    GO Terms (all 7)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tlr4ba-202 (1)    Ensembl 2553
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tlr4ba No data available
    MARKER RELATIONSHIPS
    tlr4ba Contained in: [BAC] CH211-198A12 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001131051 (1) 2328 bp
    Genomic GenBank:BX908770 (1) 126240 bp
    Select Tool
    Polypeptide UniProtKB:B8A689 (1) 787 aa
    Sequence Clusters UniGene:160845 (1)
    Sequence Information (all 17)
    ORTHOLOGY for tlr4ba ( Chr: 13 )
    CITATIONS (52)