Gene

tlr2

ID
ZDB-GENE-040219-6
Name
toll-like receptor 2
Symbol
tlr2 Nomenclature History
Previous Names
  • TIR2 (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have signaling receptor activity and triacyl lipopeptide binding activity. Involved in activation of immune response. Predicted to localize to integral component of plasma membrane. Is expressed in brain; integument; liver; and spleen. Human ortholog(s) of this gene implicated in several diseases, including dermatitis (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (toll like receptor 2).
Genome Resources
Note
None
Expression
All Expression Data
11 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tlr2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
colorectal cancer Alliance {Colorectal cancer, susceptibility to} 114500
{Leprosy, susceptibility to} 246300
{Mycobacterium tuberculosis, susceptibility to} 607948
Associated With tlr2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Family IPR017241 Toll-like receptor
Family IPR027185 Toll-like receptor 2
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Homologous_superfamily IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
Repeat IPR001611 Leucine-rich repeat
Repeat IPR003591 Leucine-rich repeat, typical subtype
Domain Details Per Protein
Protein Length Leucine-rich repeat Leucine-rich repeat domain superfamily Leucine-rich repeat, typical subtype Toll/interleukin-1 receptor homology (TIR) domain Toll/interleukin-1 receptor homology (TIR) domain superfamily Toll-like receptor Toll-like receptor 2
UniProtKB:Q6TS42 788
UniProtKB:B2MWP8 252
UniProtKB:A0A2R8Q551 788
UniProtKB:F1QWS9 818
UniProtKB:Q6TQI2 167
UniProtKB:F1R1U3 788
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations