ZFIN ID: ZDB-GENE-040219-6
Gene Name: toll-like receptor 2
Gene Symbol: tlr2    Nomenclature History

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Previous Name: TIR2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Involved in activation of immune response. Predicted to localize to the integral component of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); dermatitis (multiple); eye disease (multiple); rhinitis (multiple); and tuberculosis (multiple). Is expressed in brain; integument; liver; and spleen. Orthologous to human TLR2 (toll like receptor 2).
Genome Resources: Alliance (1),  Gene:403125 (1),  Ensembl(GRCz11):ENSDARG00000037758 (1)
GENE EXPRESSION
All Expression Data: 11 figures from 9 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu520]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6574 Point Mutation Unknown Premature Stop ENU
sa19423 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39548 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko175a Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • zko175b Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tlr2 1
    MO1-tlr2 N/A 2
    MO2-tlr2 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tlr2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    colorectal cancer Alliance {Colorectal cancer, susceptibility to} 114500
    {Leprosy, susceptibility to} 246300
    {Mycobacterium tuberculosis, susceptibility to} 607948
    DISEASE ASSOCIATED WITH tlr2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process activation of immune response (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
    Repeat IPR001611 Leucine-rich repeat
    Repeat IPR003591 Leucine-rich repeat, typical subtype
    Family IPR027185 Toll-like receptor 2
    Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
    Homologous_superfamily IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tlr2-201 (1)    Ensembl 2367
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tlr2 No data available
    MARKER RELATIONSHIPS
    tlr2 Contained in: [BAC] CH73-191K20 (1)
    tlr2 Encodes: [EST] eu520 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212812 (1) 2367 bp
    Genomic GenBank:CU467110 (1) 48844 bp
    Select Tool
    Polypeptide UniProtKB:F1QWS9 (1) 818 aa
    Sequence Information (all 20)
    ORTHOLOGY for tlr2 ( Chr: 1 )
    CITATIONS (50)