ZFIN ID: ZDB-GENE-040219-3
Gene Name: MYD88 innate immune signal transduction adaptor
Gene Symbol: myd88    Nomenclature History

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Previous Names: zMyD88 (1), zgc:103541

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have Toll-like receptor binding activity. Involved in several processes, including neutrophil activation involved in immune response; neutrophil chemotaxis; and response to bacterium. Predicted to localize to plasma membrane. Is expressed in several structures, including digestive system; hematopoietic system; pleuroperitoneal region; tail bud; and ventral fin fold. Human ortholog(s) of this gene implicated in Waldenstroem's macroglobulinemia. Orthologous to human MYD88 (MYD88 innate immune signal transduction adaptor).
Genome Resources: Alliance (1),  Gene:403145 (1),  Ensembl(GRCz11):ENSDARG00000010169 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3568 Point Mutation Unknown Premature Stop ENU
w187 Small Deletion Unknown Frameshift, Premature Stop TALEN
xt29 Small Deletion Unknown Frameshift, Premature Stop CRISPR
b1354 Small Deletion Exon 1 Premature Stop CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-myd88
1
CRISPR2-myd88
1
CRISPR3-myd88
1
CRISPR4-myd88
1
CRISPR5-myd88
1
CRISPR6-myd88 1
CRISPR7-myd88 3
CRISPR8-myd88
2
MO1-myd88 N/A 11
MO2-myd88 N/A 13
MO3-myd88 N/A 4
MO4-myd88 N/A 2
MO5-myd88 N/A 1
TALEN1-myd88 1
DISEASE ASSOCIATED WITH myd88 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Waldenstroem's macroglobulinemia Alliance Macroglobulinemia, Waldenstrom, somatic 153600
Immunodeficiency 68 612260
DISEASE ASSOCIATED WITH myd88 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process neutrophil chemotaxis (more)
Cellular Component cytoplasm (more)
Molecular Function protein binding (more)
GO Terms (all 21)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA myd88-201 (1)    Ensembl 1485
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM myd88
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(mpeg1.1:myd88_L265P) mpeg1.1 myd88 Danio rerio 1 1
Tg(myd88:DsRed2) myd88 DsRed2 Danio rerio 1 3
Tg(myd88:EGFP) myd88 EGFP Danio rerio 1 4
MARKER RELATIONSHIPS
myd88 Contained in: [BAC] CH211-227L2 (1)
myd88 Encodes: [cDNA] MGC:103541 (1), MGC:191817 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_212814 (1) 1369 nt
Genomic GenBank:BX247944 (1) 155665 nt
Select Tool
Polypeptide UniProtKB:A0A0R4I9A6 (1) 284 aa
Sequence Information (all 21)
ORTHOLOGY for myd88 ( Chr: 24 )
CITATIONS (122)