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Gene

myd88

ID
ZDB-GENE-040219-3
Name
MYD88 innate immune signal transduction adaptor
Symbol
myd88 Nomenclature History
Previous Names
  • zMyD88 (1)
  • zgc:103541
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to enable Toll-like receptor binding activity. Acts upstream of or within several processes, including neutrophil activation involved in immune response; neutrophil chemotaxis; and response to bacterium. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including digestive system; hematopoietic system; pleuroperitoneal region; tail bud; and ventral fin fold. Human ortholog(s) of this gene implicated in Waldenstroem's macroglobulinemia and primary immunodeficiency disease. Orthologous to human MYD88 (MYD88 innate immune signal transduction adaptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
21 figures from 14 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With myd88 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Waldenstroem's macroglobulinemia Alliance Macroglobulinemia, Waldenstrom, somatic 153600
Immunodeficiency 68 612260
Associated With myd88 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Domain IPR000488 Death domain
Domain IPR034249 MyD88, death domain
Family IPR017281 Myeloid differentiation primary response protein MyD88
Homologous_superfamily IPR011029 Death-like domain superfamily
Homologous_superfamily IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
Domain Details Per Protein
Protein Length Death domain Death-like domain superfamily MyD88, death domain Myeloid differentiation primary response protein MyD88 Toll/interleukin-1 receptor homology (TIR) domain Toll/interleukin-1 receptor homology (TIR) domain superfamily
UniProtKB:Q5XJ85 284
UniProtKB:B2GQ86 284
UniProtKB:A0A0R4I9A6 284
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations