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ZIRC
ZFIN ID: ZDB-GENE-040219-10
Gene Name: toll-like receptor 9
Gene Symbol: tlr9    Nomenclature History

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Previous Names: TIR9 (1), sb:eu392

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have signaling pattern recognition receptor activity. Involved in antibacterial humoral response and toll-like receptor signaling pathway. Localizes to the endoplasmic reticulum. Human ortholog(s) of this gene implicated in several diseases, including allergic bronchopulmonary aspergillosis; cystic fibrosis; glomerulonephritis (multiple); lung disease (multiple); and systemic lupus erythematosus. Is expressed in blood; heart; liver; muscle; and pleuroperitoneal region. Orthologous to human TLR9 (toll like receptor 9).
Genome Resources: Alliance (1),  Gene:403128 (1),  Ensembl(GRCz11):ENSDARG00000044490 (1)
GENE EXPRESSION
All Expression Data: 13 figures from 6 publications
Directly Submitted Expression Data: 6 figures (4 images) from Thisse et al., 2005 [eu392]
Wild-type Stages, Structures: Blastula:1k-cell (3.0h-3.33h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1171 Point Mutation Unknown Premature Stop ENU
sa10328 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12600 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34528 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tlr9 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tlr9 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process antibacterial humoral response (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function transmembrane signaling receptor activity (more)
    GO Terms (all 25)
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tlr9 No data available
    MARKER RELATIONSHIPS
    tlr9 Encodes: [EST] eu392 (1)
    [cDNA] MGC:194324 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001130594 (1) 3291 bp
    Genomic GenBank:DU644467 (1) 152 bp
    Polypeptide UniProtKB:A0A2R8QA47 (1) 1069 aa
    Sequence Clusters UniGene:89703 (1)
    Sequence Information (all 21)
    ORTHOLOGY for tlr9 ( Chr: 8 )
    CITATIONS (31)