ZFIN ID: ZDB-GENE-040218-1
Gene Name: presenilin enhancer, gamma-secretase subunit
Gene Symbol: psenen    Nomenclature History

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Previous Names: pen2 (1), zgc:109727

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Involved in developmental pigmentation; melanocyte migration; and negative regulation of neuron apoptotic process. Predicted to localize to gamma-secretase complex and integral component of membrane. Is expressed in forebrain; hindbrain; midbrain; presumptive neural retina; and trunk. Human ortholog(s) of this gene implicated in hidradenitis suppurativa. Orthologous to human PSENEN (presenilin enhancer, gamma-secretase subunit).
Genome Resources: Alliance (1),  Gene:402810 (1),  Ensembl(GRCz11):ENSDARG00000068698 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:109727]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-psenen N/A 4
MO2-psenen N/A 3
DISEASE ASSOCIATED WITH psenen HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hidradenitis suppurativa Alliance Acne inversa, familial, 2, with or without Dowling-Degos disease 613736
DISEASE ASSOCIATED WITH psenen VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process developmental pigmentation (more)
Cellular Component integral component of membrane (more)
GO Terms (all 15)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA psenen-201 (1)    Ensembl 976
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-psenen polyclonal 1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM psenen No data available
MARKER RELATIONSHIPS
psenen Contained in: [BAC] CH211-51D2 (1), CH211-137J23 (1)
psenen Encodes: [cDNA] MGC:109727 (1), MGC:191992 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_205576 (1) 1022 nt
Genomic GenBank:CT027748 (1) 166105 nt
Select Tool
Polypeptide UniProtKB:B2GQP2 (1) 101 aa
Sequence Information (all 17)
ORTHOLOGY for psenen ( Chr: 15 )
CITATIONS (28)