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Gene

psenen

ID
ZDB-GENE-040218-1
Name
presenilin enhancer, gamma-secretase subunit
Symbol
psenen Nomenclature History
Previous Names
  • pen2 (1)
  • zgc:109727
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Acts upstream of or within developmental pigmentation; melanocyte migration; and negative regulation of neuron apoptotic process. Predicted to be integral component of membrane. Predicted to be part of gamma-secretase complex. Is expressed in forebrain; hindbrain; midbrain; presumptive neural retina; and trunk. Human ortholog(s) of this gene implicated in hidradenitis suppurativa. Orthologous to human PSENEN (presenilin enhancer, gamma-secretase subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With psenen Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hidradenitis suppurativa Alliance Acne inversa, familial, 2, with or without Dowling-Degos disease 613736
Associated With psenen Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR019379 Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit
Domain Details Per Protein
Protein Length Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit
UniProtKB:B2GQP2 101
UniProtKB:Q8JHF0 101
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-psenen polyclonal
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations