Gene

cyp17a1

ID
ZDB-GENE-040213-2
Name
cytochrome P450, family 17, subfamily A, polypeptide 1
Symbol
cyp17a1 Nomenclature History
Previous Names
  • cyp17 (1)
  • P450c17 (1)
  • wu:fi13g04
  • wu:fi17b11
  • wu:fi31c08
  • zgc:136516
  • zgc:66494
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Exhibits 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity; 17-alpha-hydroxyprogesterone aldolase activity; and steroid 17-alpha-monooxygenase activity. Involved in several processes, including androst-4-ene-3,17-dione biosynthetic process; female sex determination; and progesterone metabolic process. Predicted to localize to membrane. Is expressed in Leydig cell; brain; and gonad. Human ortholog(s) of this gene implicated in several diseases, including cholelithiasis; congenital adrenal hyperplasia; gallbladder cancer; osteoporosis; and prostate cancer. Orthologous to human CYP17A1 (cytochrome P450 family 17 subfamily A member 1).
Genome Resources
Note
None
Expression
All Expression Data
26 figures from 18 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from Zhai et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cyp17a1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital adrenal hyperplasia Alliance 17,20-lyase deficiency, isolated 202110
congenital adrenal hyperplasia Alliance 17-alpha-hydroxylase/17,20-lyase deficiency 202110
Associated With cyp17a1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017972 Cytochrome P450, conserved site
Family IPR001128 Cytochrome P450
Family IPR002401 Cytochrome P450, E-class, group I
Family IPR033282 Steroid 17-alpha-hydroxylase/17,20 lyase
Homologous_superfamily IPR036396 Cytochrome P450 superfamily
Domain Details Per Protein
Protein Length Cytochrome P450 Cytochrome P450, conserved site Cytochrome P450, E-class, group I Cytochrome P450 superfamily Steroid 17-alpha-hydroxylase/17,20 lyase
UniProtKB:B3DH80 519
UniProtKB:Q6PFI1 519
UniProtKB:A2ATX9 519
UniProtKB:Q1ECZ3 519
UniProtKB:Q7T3J1 519
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cyp17a1 Rabbit
  • IHC
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations