ZFIN ID: ZDB-GENE-040213-2
Gene Name: cytochrome P450, family 17, subfamily A, polypeptide 1
Gene Symbol: cyp17a1
Previous Names: cyp17 (1), P450c17 (1), wu:fi13g04, wu:fi17b11, wu:fi31c08, zgc:136516, zgc:66494
Location: Chr: 13   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 9 figures from 6 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7157435]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  brain, Leydig cell, ovarian follicle, ovarian follicle stage I (all 11) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-cyp17a1 (1)

Allele Type Mutagen Suppliers
sa22316 Point Mutation ENU
PHENOTYPE No data available
DISEASE ASSOCIATED WITH cyp17a1 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
congenital adrenal hyperplasia 17,20-lyase deficiency, isolated 202110
17-alpha-hydroxylase/17,20-lyase deficiency 202110
GENE ONTOLOGY
Ontology GO Term
Biological Process androst-4-ene-3,17-dione biosynthetic process (more)
Molecular Function 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity (more)
GO Terms (all 12)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001128 (1)
  • InterPro:IPR002401 (1)
  • InterPro:IPR017972 (1)
  • PROSITE:PS00086 (1)
  • Pfam:PF00067 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA cyp17a1-001 (1) 2799
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-cyp17a1 (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyp17a1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    cyp17a1 Contained in: [BAC] CH211-67N3 (1) (order this)
    cyp17a1 Contains: [SNP] rs3728563 (1), rs3728564 (1), rs3728565 (1)
    cyp17a1 Encodes: [EST] fi13g04, fi17b11, fi31c08, IMAGE:7157435 (1) (order this)
    [cDNA] MGC:66494 (1) (order this), MGC:136516 (1) (order this), MGC:194068 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212806 (1) 2799 bp
    Genomic GenBank:AL928951 (1) 183050 bp
    Select Tool
    Polypeptide UniProtKB:A2ATX9 (1) 519 aa
    Sequence Clusters UniGene:109966 (1)
    Sequence Information (all 37)
    OTHER cyp17a1 GENE PAGES
  • Gene:399692 (1)
  • VEGA:OTTDARG00000018827 (1)
  • Ensembl(Zv9):ENSDARG00000033566 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish cyp17a1 13  
    Human CYP17A1 10 (10q24.3)
  • OMIM:609300
  • Gene:1586
  • Mouse Cyp17a1 19 ( 38.97 cM)
  • MGI:88586
  • Gene:13074
  • Orthology Details
    CITATIONS (54)