Gene

cdkn1ca

ID
ZDB-GENE-040123-1
Name
cyclin-dependent kinase inhibitor 1Ca
Symbol
cdkn1ca Nomenclature History
Previous Names
  • cb961 (1)
  • cdkn1c
  • p21-like (1)
  • p27Xic1-a (1)
  • p57kip2 (1)
  • zgc:86618
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have cyclin-dependent protein serine/threonine kinase inhibitor activity and kinase activity. Involved in cell fate specification; glial cell differentiation; and negative regulation of mitotic cell cycle. Predicted to localize to nucleus. Is expressed in several structures, including mesoderm; muscle; nervous system; neural tube; and notochord. Human ortholog(s) of this gene implicated in Beckwith-Wiedemann syndrome; IMAGe syndrome; and hyperinsulinism. Orthologous to human CDKN1C (cyclin dependent kinase inhibitor 1C).
Genome Resources
Note
None
Expression
All Expression Data
45 figures from 32 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Osborn et al., 2011
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cdkn1ca Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Beckwith-Wiedemann syndrome Alliance Beckwith-Wiedemann syndrome 130650
IMAGe syndrome Alliance IMAGE syndrome 614732
Associated With cdkn1ca Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003175 Cyclin-dependent kinase inhibitor domain
Family IPR029842 Cyclin-dependent kinase inhibitor 1C
Domain Details Per Protein
Protein Length Cyclin-dependent kinase inhibitor 1C Cyclin-dependent kinase inhibitor domain
UniProtKB:Q6IQT7 212
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations