ZFIN ID: ZDB-GENE-040120-4
Gene Name: dihydrolipoamide dehydrogenase
Gene Symbol: dldh
Previous Names: fb24b05, wu:fb24b05 (1)
Location: Chr: 25   Details
Nomenclature History
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2004 [IMAGE:7151702]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Hatching:Long-pec (48.0h-60.0h)
  adaxial cell, immature eye, liver, midbrain (all 10) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Targeting reagents: MO1-dldh (1)
PHENOTYPE
Data: Fig. 4 from Ke├čler et al., 2015
Observed in: heart contraction, pericardium
DISEASE ASSOCIATED WITH dldh HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
maple syrup urine disease Dihydrolipoamide dehydrogenase deficiency 246900
GENE ONTOLOGY
Ontology GO Term
Biological Process heart contraction (more)
Molecular Function dihydrolipoyl dehydrogenase activity (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001327 (1)
  • InterPro:IPR004099 (1)
  • InterPro:IPR006258 (1)
  • InterPro:IPR012999 (1)
  • InterPro:IPR016156 (1)
  • InterPro:IPR023753 (1)
  • PROSITE:PS00076 (1)
  • Pfam:PF00070 (1)
  • Pfam:PF02852 (1)
  • Pfam:PF07992 (1)
  • EC:1.8.1.4 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA dldh-001 (1) 1806
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dldh No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    dldh Contained in: [BAC] DKEY-42P14 (1) (order this)
    dldh Encodes: [EST] fb24b05, IMAGE:7151702 (1) (order this)
    [cDNA] MGC:55583 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_201506 (1) 1805 bp
    Genomic GenBank:CR376804 (1) 117107 bp
    Select Tool
    Polypeptide UniProtKB:Q6TNU6 (1) 507 aa
    Sequence Clusters UniGene:76179 (1)
    Sequence Information (all 14)
    OTHER dldh GENE PAGES
  • Gene:399479 (1)
  • VEGA:OTTDARG00000021231 (1)
  • Ensembl(Zv9):ENSDARG00000008785 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA
    Zebrafish dldh 25  
    Human DLD 7 (7q31-q32)
  • OMIM:238331
  • Gene:1738
  • Orthology Details
    CITATIONS (18)