Gene
gfi1ab
- ID
- ZDB-GENE-040116-8
- Name
- growth factor independent 1A transcription repressor b
- Symbol
- gfi1ab Nomenclature History
- Previous Names
-
- gfi1.2
- gfi1
- gfi1b
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hair cell differentiation and peripheral nervous system development. Predicted to be located in nucleus. Is expressed in anterior lateral mesoderm; nervous system; otic vesicle; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in acute myeloid leukemia and severe congenital neutropenia 2. Orthologous to human GFI1 (growth factor independent 1 transcriptional repressor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 36 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Yu et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| severe congenital neutropenia 2 | Alliance | Neutropenia, severe congenital 2, autosomal dominant | 613107 |
| ?Neutropenia, nonimmune chronic idiopathic, of adults | 607847 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C2H2-type Zinc-Finger Transcription Regulators | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|
| UniProtKB:Q7SZV1 | InterPro | 396 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gfi1ab-201
(1)
|
Ensembl | 1,228 nt |
Interactions and Pathways
No data available
Plasmids
No data available