Gene

gfi1ab

ID
ZDB-GENE-040116-8
Name
growth factor independent 1A transcription repressor b
Symbol
gfi1ab Nomenclature History
Previous Names
  • gfi1.2
  • gfi1
  • gfi1b
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have DNA binding activity and DNA-binding transcription factor activity. Involved in peripheral nervous system development. Predicted to localize to nucleus. Is expressed in anterior lateral mesoderm; nervous system; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in acute myeloid leukemia and severe congenital neutropenia. Orthologous to human GFI1 (growth factor independent 1 transcriptional repressor).
Genome Resources
Note
None
Expression
All Expression Data
32 figures from 19 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gfi1ab Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Neutropenia, severe congenital 2, autosomal dominant 613107
?Neutropenia, nonimmune chronic idiopathic, of adults 607847
Associated With gfi1ab Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:F1QKD4 396
UniProtKB:Q7SZV1 396
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations