ZFIN ID: ZDB-GENE-040116-5
Gene Name: FA complementation group D2
Gene Symbol: fancd2    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have DNA polymerase binding activity. Involved in negative regulation of apoptotic process. Predicted to localize to condensed chromosome and nucleus. Is expressed in brain; eye; immature eye; and lens. Human ortholog(s) of this gene implicated in Fanconi anemia; Fanconi anemia complementation group D2; and breast cancer. Orthologous to human FANCD2 (FA complementation group D2).
Genome Resources: Alliance (1),  Gene:394241 (1),  Ensembl(GRCz11):ENSDARG00000053574 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hg46 Small Deletion Unknown Unknown CRISPR
hg47 Small Deletion Exon 16 Unknown CRISPR
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la025577Tg Transgenic Insertion Unknown Unknown DNA
    sa7045 Point Mutation Unknown Splice Site ENU
    sa9077 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18469 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20788 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20789 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20790 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-fancd2 1
    MO1-fancd2 N/A 2
    DISEASE ASSOCIATED WITH fancd2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Fanconi anemia complementation group D2 Alliance Fanconi anemia, complementation group D2 227646
    DISEASE ASSOCIATED WITH fancd2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of apoptotic process (more)
    Cellular Component condensed chromosome (more)
    Molecular Function DNA polymerase binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fancd2-201 (1)    Ensembl 4762
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fancd2 No data available
    MARKER RELATIONSHIPS
    fancd2 Contained in: [BAC] DKEY-178O3 (1) (order this)
    fancd2 Encodes: [cDNA] MGC:193568 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201341 (1) 4791 nt
    Genomic GenBank:BX957236 (1) 211391 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B3DJT4 (1) 1445 aa
    Sequence Information (all 17)
    ORTHOLOGY for fancd2 ( Chr: 6 )
    CITATIONS (27)