ZFIN ID: ZDB-GENE-040108-2
Gene Name: cholinergic receptor, nicotinic, alpha 2a (neuronal)
Gene Symbol: chrna2a    Nomenclature History

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Previous Names: chrna2 (1), zgc:136717

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Contributes to acetylcholine receptor activity. Involved in behavioral response to nicotine. Localizes to acetylcholine-gated channel complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 4. Orthologous to human CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit).
Genome Resources: Alliance (1),  Gene:678575 (1),  Ensembl(GRCz11):ENSDARG00000006602 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa28784 Point Mutation Unknown Premature Stop ENU
sa36297 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-chrna2a N/A 1
    MO2-chrna2a N/A 1
    DISEASE ASSOCIATED WITH chrna2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant nocturnal frontal lobe epilepsy 4 Alliance Epilepsy, nocturnal frontal lobe, type 4 610353
    DISEASE ASSOCIATED WITH chrna2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process behavioral response to nicotine (more)
    Cellular Component acetylcholine-gated channel complex (more)
    Molecular Function CONTRIBUTES_TO   acetylcholine receptor activity (more)
    GO Terms (all 24)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA chrna2a-201 (1)    Ensembl 2368
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-chrna2a polyclonal Rabbit IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM chrna2a No data available
    MARKER RELATIONSHIPS
    chrna2a Contained in: [BAC] CH73-51D8 (1), CH73-339L24 (1)
    chrna2a Contains: [STS] chunp40142 (1)
    chrna2a Encodes: [cDNA] MGC:136717 (1), MGC:193799 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001040327 (1) 2390 nt
    Genomic GenBank:CU571076 (1) 100888 nt
    Select Tool
    Polypeptide UniProtKB:B3DGY1 (1) 520 aa
    Sequence Information (all 19)
    ORTHOLOGY for chrna2a ( Chr: 17 )
    CITATIONS (28)