ZFIN ID: ZDB-GENE-031222-5
Gene Name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a
Gene Symbol: hadhaa    Nomenclature History

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Previous Names: hadha, cb1055 (1), im:7136067, wu:fa14c08

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have enoyl-CoA hydratase activity and long-chain-3-hydroxyacyl-CoA dehydrogenase activity. Involved in response to bacterium. Predicted to localize to mitochondrial fatty acid beta-oxidation multienzyme complex. Is expressed in several structures, including cardiovascular system; midbrain; midbrain neural tube; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in fatty liver disease and mitochondrial trifunctional protein deficiency. Orthologous to human HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha).
Genome Resources: Alliance (1),  Gene:553401 (1),  Ensembl(GRCz11):ENSDARG00000057128 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa414 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31050 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hadhaa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    mitochondrial trifunctional protein deficiency Alliance Trifunctional protein deficiency 609015
    Fatty liver, acute, of pregnancy 609016
    HELLP syndrome, maternal, of pregnancy 609016
    LCHAD deficiency 609016
    DISEASE ASSOCIATED WITH hadhaa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to bacterium (more)
    Cellular Component mitochondrial fatty acid beta-oxidation multienzyme complex (more)
    Molecular Function 3-hydroxyacyl-CoA dehydrogenase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hadhaa-201 (1)    Ensembl 2782
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hadhaa No data available
    MARKER RELATIONSHIPS
    hadhaa Contained in: [BAC] CH73-135O10 (1), CH211-161E1 (1)
    hadhaa Encodes: [EST] cb1055 (1) (order this), fa14c08, IMAGE:7136067
    [cDNA] MGC:136649 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001105276 (1) 2785 nt
    Genomic GenBank:CU138532 (1) 133488 nt
    Select Tool
    Polypeptide UniProtKB:A7YT47 (1) 761 aa
    Sequence Information (all 17)
    ORTHOLOGY for hadhaa ( Chr: 20 )
    CITATIONS (29)