ZFIN ID: ZDB-GENE-031219-7
Gene Name: myosin VB
Gene Symbol: myo5b    Nomenclature History

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Previous Names: cb1077 (1), gsp, si:ch73-112l6.5, unm t30834, unm t30835, unm_t30834, unm_t30835

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in several processes, including digestive tract morphogenesis; intestinal lipid absorption; and skin development. Predicted to localize to the myosin complex. Used to study microvillus inclusion disease. Human ortholog(s) of this gene implicated in microvillus inclusion disease. Is expressed in several structures, including EVL; gut; periderm; pronephric duct; and sensory system. Orthologous to human MYO5B (myosin VB).
Genome Resources: Alliance (1),  Gene:567402 (1),  Ensembl(GRCz11):ENSDARG00000062003 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa3127 Point Mutation Unknown Premature Stop ENU
sa37296 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43638 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t30834 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • t30835 Point Mutation Unknown Exon Loss of Exon 10, Frameshift, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tk34a Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tk38 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tt221 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • uq23ks Point Mutation Unknown Frameshift, Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-myo5b N/A 1
    MO2-myo5b N/A 1
    MO3-myo5b N/A 1
    DISEASE ASSOCIATED WITH myo5b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    microvillus inclusion disease Alliance Microvillus inclusion disease 251850
    DISEASE ASSOCIATED WITH myo5b VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    microvillus inclusion disease myo5bt30834/t30834 standard conditions Sidhaye et al., 2016
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon development (more)
    Cellular Component myosin complex (more)
    Molecular Function actin binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Binding_site IPR000048 IQ motif, EF-hand binding site
    Domain IPR001609 Myosin head, motor domain
    Domain IPR002710 Dilute domain
    Domain IPR004009 Myosin, N-terminal, SH3-like
    Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Domain IPR036103 Class V myosin, motor domain
    Homologous_superfamily IPR036961 Kinesin motor domain superfamily
    Domain IPR037990 Myosin 5b, cargo-binding domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA myo5b-202 (1)    Ensembl 828
    myo5b-203 (1)    Ensembl 7698
    myo5b-204 (1)    Ensembl 854
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM myo5b No data available
    MARKER RELATIONSHIPS
    myo5b Contained in: [BAC] CH73-112L6 (1), CH73-203I3 (1), CH211-257I19 (1)
    myo5b Encodes: [EST] cb1077 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001161632 (1) 5662 bp
    Genomic GenBank:BX530035 (1) 179729 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IPW9 (1) 1839 aa
    Sequence Information (all 27)
    ORTHOLOGY for myo5b ( Chr: 21 )
    CITATIONS (31)