ZFIN ID: ZDB-GENE-031219-6
Gene Name: adenosylhomocysteinase
Gene Symbol: ahcy
Previous Names: cb1079 (1), dtp (1), hm:zeh1173 (1), hm:zeh1364, wu:fj67b02, zeh1173
Location: Chr: 6   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 8 figures from 4 publications
Directly Submitted Expression Data: 4 figures (6 images) from Thisse et al., 2001 [cb1079]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  alar plate midbrain region, cerebellum, diencephalon, immature eye (all 19) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 2 Genotypes
Knockdown reagents: MO1-ahcy (1), MO2-ahcy (1)

Allele Type Mutagen Suppliers
la025635Tg Transgenic Insertion DNA
p14nb Unknown ENU
PHENOTYPE
Data: 4 figures from 3 publications
Observed in: bile ductule, exocrine pancreas, gall bladder, hepatocyte mitochondrial crista (all 12) expand
DISEASE ASSOCIATED WITH ahcy HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
hypermethioninemia Hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase 613752
GENE ONTOLOGY
Ontology GO Term
Biological Process S-adenosylmethionine cycle (more)
Cellular Component cytosol (more)
Molecular Function adenosylhomocysteinase activity (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000043 (1)
  • InterPro:IPR015878 (1)
  • InterPro:IPR016040 (1)
  • InterPro:IPR020082 (1)
  • PROSITE:PS00738 (1)
  • Pfam:PF00670 (1)
  • Pfam:PF05221 (1)
  • EC:3.3.1.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ahcy-001 (1) 1922
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ahcy No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    ahcy Contained in: [BAC] DKEY-16N21 (1) (order this)
    ahcy Encodes: [EST] cb1079 (1) (order this), fj67b02 (1), zeh1173, zeh1364 (1)
    [cDNA] MGC:55617 (1) (order this), MGC:191701 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199218 (1) 1940 bp
    Genomic GenBank:BX629346 (1) 214213 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q803T5 (1) 433 aa
    Sequence Clusters UniGene:935 (1)
    Sequence Information (all 23)
    OTHER ahcy GENE PAGES
  • Gene:387530 (1)
  • VEGA:OTTDARG00000019930 (1)
  • Ensembl(Zv9):ENSDARG00000005191 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish ahcy 6  
    Human AHCY 20 (20q11.22)
  • OMIM:180960
  • Gene:191
  • Mouse Ahcy 2 ( 76.94 cM)
  • MGI:87968
  • Gene:269378
  • Orthology Details
    CITATIONS (37)