ZFIN ID: ZDB-GENE-031219-6
Gene Name: adenosylhomocysteinase
Gene Symbol: ahcy    Nomenclature History

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Previous Names: cb1079 (1), dtp (1), ducttrip (1), hm:zeh1173 (1), hm:zeh1364, wu:fj67b02, zeh1173

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have adenosylhomocysteinase activity. Involved in S-adenosylmethionine cycle. Predicted to localize to cytosol. Is expressed in several structures, including brain; digestive system; immature eye; musculature system; and neural tube. Used to study fatty liver disease and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase. Orthologous to human AHCY (adenosylhomocysteinase).
Genome Resources: Alliance (1),  Gene:387530 (1),  Ensembl(GRCz11):ENSDARG00000005191 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la025635Tg Transgenic Insertion Unknown Unknown DNA
p14nb Point Mutation Exon 8 Missense ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-ahcy N/A 1
MO2-ahcy N/A 2
DISEASE ASSOCIATED WITH ahcy HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase Alliance Hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase 613752
DISEASE ASSOCIATED WITH ahcy VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
fatty liver disease ahcyp14nb/p14nb standard conditions (2)
non-alcoholic fatty liver disease ahcyp14nb/+ control Sapp et al., 2014
GENE ONTOLOGY
Ontology GO Term
Biological Process S-adenosylmethionine cycle (more)
Cellular Component cytosol (more)
Molecular Function adenosylhomocysteinase activity (more)
GO Terms (all 4)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ahcy-201 (1)    Ensembl 1922
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ahcy No data available
MARKER RELATIONSHIPS
ahcy Contained in: [BAC] DKEY-16N21 (1) (order this)
ahcy Encodes: [EST] cb1079 (1) (order this), fj67b02 (1), zeh1173, zeh1364 (1)
[cDNA] MGC:55617 (1), MGC:191701 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_199218 (1) 1940 nt
Genomic GenBank:BX629346 (1) 214213 nt Blast at MegaBLAST
Polypeptide UniProtKB:Q803T5 (1) 433 aa
Sequence Information (all 23)
ORTHOLOGY for ahcy ( Chr: 6 )
CITATIONS (47)