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ZIRC
ZFIN ID: ZDB-GENE-031219-6
Gene Name: adenosylhomocysteinase
Gene Symbol: ahcy    Nomenclature History

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Previous Names: cb1079 (1), dtp (1), ducttrip (1), hm:zeh1173 (1), hm:zeh1364, wu:fj67b02, zeh1173

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have adenosylhomocysteinase activity. Involved in S-adenosylmethionine cycle. Predicted to localize to the cytosol. Used to study fatty liver disease and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase. Is expressed in several structures, including brain; digestive system; immature eye; musculature system; and neural tube. Orthologous to human AHCY (adenosylhomocysteinase).
Genome Resources: Alliance (1),  Gene:387530 (1),  Ensembl(GRCz11):ENSDARG00000005191 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la025635Tg Transgenic Insertion Unknown Unknown DNA
p14nb Point Mutation Exon 8 Missense ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-ahcy N/A 1
MO2-ahcy N/A 2
DISEASE ASSOCIATED WITH ahcy HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase Alliance Hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase 613752
DISEASE ASSOCIATED WITH ahcy VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
fatty liver disease ahcyp14nb/p14nb standard conditions (2)
non-alcoholic fatty liver disease ahcyp14nb/+ control Sapp et al., 2014
GENE ONTOLOGY
Ontology GO Term
Biological Process S-adenosylmethionine cycle (more)
Cellular Component cytosol (more)
Molecular Function adenosylhomocysteinase activity (more)
GO Terms (all 4)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ahcy-201 (1)    Ensembl 1922
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ahcy No data available
MARKER RELATIONSHIPS
ahcy Contained in: [BAC] DKEY-16N21 (1) (order this)
ahcy Encodes: [EST] cb1079 (1) (order this), fj67b02 (1), zeh1173, zeh1364 (1)
[cDNA] MGC:55617 (1) (order this), MGC:191701 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_199218 (1) 1940 bp
Genomic GenBank:BX629346 (1) 214213 bp Blast at MegaBLAST
Polypeptide UniProtKB:Q803T5 (1) 433 aa
Sequence Clusters UniGene:935 (1)
Sequence Information (all 24)
ORTHOLOGY for ahcy ( Chr: 6 )
CITATIONS (46)