Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-031219-6
Gene Name: adenosylhomocysteinase
Gene Symbol: ahcy
Previous Names: cb1079 (1), dtp (1), hm:zeh1173 (1), hm:zeh1364, wu:fj67b02, zeh1173
Location: Chr: 6   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 8 figures from 4 publications
Directly Submitted Expression Data: 4 figures (6 images) from Thisse et al., 2001 [cb1079]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  alar plate midbrain region, cerebellum, diencephalon, immature eye (all 19) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 2 genotypes
Alleles: la025635Tg, p14nb
Knockdown reagents: MO1-ahcy (1), MO2-ahcy (1)
PHENOTYPE
Data: 4 figures from 3 publications
Observed in: bile ductule, exocrine pancreas, gall bladder, hepatocyte mitochondrial crista (all 12) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase 613752
GENE ONTOLOGY
Ontology GO Term
Biological Process S-adenosylmethionine cycle (more)
Molecular Function adenosylhomocysteinase activity (more)
GO Terms (all 4)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000043 (1)
  • InterPro:IPR015878 (1)
  • InterPro:IPR016040 (1)
  • InterPro:IPR020082 (1)
  • PROSITE:PS00738 (1)
  • Pfam:PF00670 (1)
  • Pfam:PF05221 (1)
  • EC:3.3.1.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ahcy-001 (1) 1922
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ahcy No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    ahcy Contained in: [BAC] DKEY-16N21 (1)
    ahcy Encodes: [EST] cb1079 (1) (order this), fj67b02 (1), zeh1173, zeh1364 (1)
    [cDNA] MGC:55617 (1) (order this), MGC:191701 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199218 (1) 1940 bp
    Genomic GenBank:BX629346 (1) 214213 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q803T5 (1) 433 aa
    Sequence Clusters UniGene:935 (1)
    Sequence Information (all 23)
    OTHER ahcy GENE PAGES
  • Gene:387530 (1)
  • VEGA:OTTDARG00000019930 (1)
  • Ensembl(Zv9):ENSDARG00000005191 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish ahcy 6  
    Human AHCY 20 (20q11.22)
  • OMIM:180960
  • Gene:191
  • Mouse Ahcy 2 ( 76.94 cM)
  • MGI:87968
  • Gene:269378
  • Orthology Details
    CITATIONS (35)