ZFIN ID: ZDB-GENE-031219-1
Gene Name: four and a half LIM domains 1b
Gene Symbol: fhl1b    Nomenclature History

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Previous Names: fhl, cb1039 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have ion channel binding activity. Involved in animal organ development; calcium ion homeostasis; and locomotory behavior. Is expressed in several structures, including cardiovascular system; digestive system; hypochord; liver primordium; and musculature system. Human ortholog(s) of this gene implicated in X-linked Emery-Dreifuss muscular dystrophy 6. Orthologous to human FHL1 (four and a half LIM domains 1).
Genome Resources: Alliance (1),  Gene:387528 (1),  Ensembl(GRCz11):ENSDARG00000056653 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh351 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • fh352 Point Mutation Unknown Unknown ENU
    fhl1b_unrecovered Point Mutation Unknown Unknown ENU
    sa41673 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-fhl1b
    1
    CRISPR2-fhl1b
    1
    MO1-fhl1b N/A 2
    MO2-fhl1b N/A 1
    MO3-fhl1b N/A 1
    DISEASE ASSOCIATED WITH fhl1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    reducing body myopathy 1A Alliance Reducing body myopathy, X-linked 1a, severe, infantile or early childhood onset 300717
    reducing body myopathy 1B Alliance Reducing body myopathy, X-linked 1b, with late childhood or adult onset 300718
    scapuloperoneal myopathy Alliance Scapuloperoneal myopathy, X-linked dominant 300695
    X-linked Emery-Dreifuss muscular dystrophy 6 Alliance Emery-Dreifuss muscular dystrophy 6, X-linked 300696
    Myopathy, X-linked, with postural muscle atrophy 300696
    ?Uruguay faciocardiomusculoskeletal syndrome 300280
    DISEASE ASSOCIATED WITH fhl1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process calcium ion homeostasis (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fhl1b-202 (1)    Ensembl 1444
    ncRNA fhl1b-002 (1)    Ensembl 927
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fhl1b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(HSE:fhl1b,GFP) HSE fhl1bGFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    fhl1b Contained in: [BAC] CH73-52F15 (1)
    fhl1b Encodes: [EST] cb1039 (1) (order this)
    [cDNA] MGC:64143 (1), MGC:174826 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199217 (1) 1512 nt
    Genomic GenBank:CU468967 (1) 131614 nt
    Select Tool
    Polypeptide UniProtKB:B0JZK9 (1) 280 aa
    Sequence Information (all 16)
    ORTHOLOGY for fhl1b ( Chr: 10 )
    CITATIONS (26)