Gene
jam2a
- ID
- ZDB-GENE-031204-3
- Name
- junctional adhesion molecule 2a
- Symbol
- jam2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Exhibits protein heterodimerization activity. Involved in hematopoietic or lymphoid organ development and myoblast fusion. Predicted to localize to integral component of plasma membrane; protein complex involved in cell adhesion; and tight junction. Is expressed in several structures, including blood vessel; musculature system; myoblast; nervous system; and pectoral fin bud. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human JAM2 (junctional adhesion molecule 2).
- Genome Resources
- Note
- None
- All Expression Data
- 14 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Basal ganglia calcification, idiopathic, 8, autosomal recessive | 618824 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013106 | Immunoglobulin V-set domain |
| Family | IPR042625 | Junctional adhesion molecule B |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype | Immunoglobulin subtype 2 | Immunoglobulin V-set domain | Junctional adhesion molecule B |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IGV4
|
307 | |||||||
|
UniProtKB:E9QBR0
|
185 | |||||||
|
UniProtKB:A4JYM3
|
307 | |||||||
|
UniProtKB:F1QQJ8
|
98 |
Interactions and Pathways
No data available
Plasmids