ZFIN ID: ZDB-GENE-031204-3
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Gene Name: junctional adhesion molecule 2a
Gene Symbol: jam2a    Nomenclature History

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Previous Names: jam2, jamb.1 (1), jamb (1), sb:cb1002

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Exhibits protein heterodimerization activity. Involved in hematopoietic or lymphoid organ development and myoblast fusion. Predicted to localize to the integral component of membrane. Is expressed in several structures, including blood vessel; musculature system; myoblast; nervous system; and pectoral fin bud. Orthologous to human JAM2 (junctional adhesion molecule 2).
Genome Resources: Alliance (1),  Gene:100005261 (1),  Ensembl(GRCz11):ENSDARG00000058996 (2)
GENE EXPRESSION
All Expression Data: 14 figures from 7 publications
Directly Submitted Expression Data: 5 figures (11 images) from Thisse et al., 2001 [cb1002]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3319 Point Mutation Unknown Premature Stop ENU
sa39528 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • zko30a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
    • zko30b Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-jam2a 1
    MO1-jam2a N/A 3
    MO2-jam2a N/A 1
    PHENOTYPE
    Data: 6 figures from 3 publications
    Observed in:
    DISEASE ASSOCIATED WITH jam2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH jam2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process myoblast fusion (more)
    Cellular Component integral component of plasma membrane (more)
    Molecular Function protein binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR003598 Immunoglobulin subtype 2
    Domain IPR003599 Immunoglobulin subtype
    Domain IPR007110 Immunoglobulin-like domain
    Domain IPR013106 Immunoglobulin V-set domain
    Family IPR042625 Junctional adhesion molecule B
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA jam2a-201 (1)    Ensembl 450
    Select Tool
    jam2a-202 (1)    Ensembl 707
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS
    Addgene:jam2a-pCRII
    CONSTRUCTS WITH SEQUENCES FROM jam2a No data available
    MARKER RELATIONSHIPS
    jam2a Contained in: [BAC] CH73-41E3 (1)
    jam2a Encodes: [EST] cb1002 (1) (order this)
    [cDNA] cssl:d187 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001098264 (1)
    Select Tool
    Genomic GenBank:CU571081 (1) 130071 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IGV4 (1) 307 aa
    Select Tool
    Sequence Information (all 12)
    ORTHOLOGY for jam2a ( Chr: 1 )
    CITATIONS (37)