ZFIN Gene: jam2a

ZFIN ID: ZDB-GENE-031204-3

ZFIN ID: ZDB-GENE-031204-3

Gene Name:

junctional adhesion molecule 2a

Gene Symbol:

jam2a Nomenclature History

Previous Names:

jam2, jamb.1 (1), jamb (1), sb:cb1002

Gene Type:

protein_coding_gene

Location:

Chr: 1 Mapping Details/Browsers

Description:

Exhibits protein heterodimerization activity. Involved in hematopoietic or lymphoid organ development and myoblast fusion. Predicted to localize to the integral component of membrane. Is expressed in several structures, including blood vessel; musculature system; myoblast; nervous system; and pectoral fin bud. Orthologous to human JAM2 (junctional adhesion molecule 2).

Genome Resources:

Alliance (1), Gene:100005261 (1), Ensembl(GRCz11):ENSDARG00000058996 (2)

GENE EXPRESSION
All Expression Data:	13 figures from 6 publications
Directly Submitted Expression Data:	5 figures (11 images) from Thisse et al., 2001 [cb1002]
Wild-type Stages, Structures:	Segmentation:1-4 somites (10.33h-11.66h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
	artery brain cranium mesoderm epaxial myotome region fast muscle myoblast forebrain gut head head muscle hypaxial myotome region musculature system myoblast myotome otic placode otic vesicle pectoral fin pectoral fin bud pectoral fin musculature somite epithelium somite mesenchyme somite posterior side somite vein
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
hu3319	Point Mutation	Unknown	Premature Stop	ENU
sa39528	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
zko30a	Small Deletion	Unknown	Unknown	CRISPR	China Zebrafish Resource Center (CZRC) (order this)
zko30b	Indel	Unknown	Unknown	CRISPR	China Zebrafish Resource Center (CZRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-jam2a	zko30a zko30b	1
MO1-jam2a	N/A	3
MO2-jam2a	N/A	1

PHENOTYPE

Data:	5 figures from 2 publications
Observed in:	angioblast cell migration from lateral mesoderm to midline fast muscle cell myoblast fusion posterior lateral mesoderm cell

DISEASE ASSOCIATED WITH jam2a HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH jam2a VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	myoblast fusion (more)
Cellular Component	integral component of plasma membrane (more)
Molecular Function	protein binding (more)

GO Terms (all 10)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR003598 (1) InterPro:IPR003599 (1) InterPro:IPR007110 (1) InterPro:IPR013106 (1) InterPro:IPR013783 (1) InterPro:IPR036179 (1) InterPro:IPR042625 (1)	PROSITE:PS50835 (1)	Pfam:PF07686 (1)

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	jam2a-201 (1)	450	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	jam2a-202 (1)	707	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS

Addgene:jam2a-pCRII

CONSTRUCTS WITH SEQUENCES FROM jam2a No data available

MARKER RELATIONSHIPS

jam2a Contained in:	[BAC] CH73-41E3 (1) (order this)
jam2a Encodes:	[EST] cb1002 (1) (order this) [cDNA] cssl:d187 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_001098264 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:CU571081 (1)	130071 bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A0R4IGV4 (1)	307 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:79413 (1)

Sequence Information (all 13)

ORTHOLOGY for jam2a ( Chr: 1 )

CITATIONS (35)

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