Gene

jam2a

ID
ZDB-GENE-031204-3
Name
junctional adhesion molecule 2a
Symbol
jam2a Nomenclature History
Previous Names
  • jam2
  • jamb.1 (1)
  • jamb (1)
  • sb:cb1002
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Exhibits protein heterodimerization activity. Involved in hematopoietic or lymphoid organ development and myoblast fusion. Predicted to localize to integral component of plasma membrane; protein complex involved in cell adhesion; and tight junction. Is expressed in several structures, including blood vessel; musculature system; myoblast; nervous system; and pectoral fin bud. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human JAM2 (junctional adhesion molecule 2).
Genome Resources
Note
None
Expression
All Expression Data
14 figures from 7 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With jam2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Basal ganglia calcification, idiopathic, 8, autosomal recessive 618824
Associated With jam2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013106 Immunoglobulin V-set domain
Family IPR042625 Junctional adhesion molecule B
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Immunoglobulin V-set domain Junctional adhesion molecule B
UniProtKB:A0A0R4IGV4 307
UniProtKB:E9QBR0 185
UniProtKB:A4JYM3 307
UniProtKB:F1QQJ8 98
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations