Gene

foxi3a

ID
ZDB-GENE-031126-3
Name
forkhead box I3a
Symbol
foxi3a Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in epidermal cell fate specification; ionocyte differentiation; and water homeostasis. Predicted to localize to nuclear chromatin. Is expressed in ectoderm; integument; ionocyte; ionocyte progenitor cell; and yolk. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 4. Orthologous to several human genes including FOXI1 (forkhead box I1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
30 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With foxi3a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Craniofacial microsomia 2 620444
Associated With foxi3a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018122 Fork head domain conserved site1
Conserved_site IPR030456 Fork head domain conserved site 2
Domain IPR001766 Fork head domain
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Fork head domain Fork head domain conserved site1 Fork head domain conserved site 2 Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:A3KNJ3 353
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA foxi3a-201 (1) Havana 1592 nt
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-foxi3a polyclonal Rabbit
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations