ZFIN ID: ZDB-GENE-031116-67
Gene Name: peptidyl arginine deiminase, type II
Gene Symbol: padi2    Nomenclature History

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Previous Names: sb:cb968, zgc:66317

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have protein-arginine deiminase activity. Involved in vasculature development. Predicted to localize to the cytoplasm and nucleus. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Is expressed in epidermis; pectoral fin musculature; periderm; pharynx; and sensory system. Orthologous to several human genes including PADI2 (peptidyl arginine deiminase 2).
Genome Resources: Alliance (1),  Gene:386792 (1),  Ensembl(GRCz11):ENSDARG00000044167 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa38578 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40787 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-padi2 N/A 1
    MO2-padi2 N/A 1
    MO3-padi2 N/A 1
    DISEASE ASSOCIATED WITH padi2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH padi2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process vasculature development (more)
    Cellular Component cytoplasm (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR004303 Protein-arginine deiminase
    Homologous_superfamily IPR008972 Cupredoxin
    Domain IPR013530 Protein-arginine deiminase, C-terminal
    Domain IPR013732 Protein-arginine deiminase (PAD) N-terminal
    Domain IPR013733 Protein-arginine deiminase (PAD), central domain
    Homologous_superfamily IPR036556 Protein-arginine deiminase, central domain superfamily
    Homologous_superfamily IPR038685 PAD, N-terminal domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA padi2-201 (1)    Ensembl 2562
    padi2-202 (1)    Ensembl 965
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM padi2 No data available
    MARKER RELATIONSHIPS
    padi2 Contained in: [BAC] DKEY-42O15 (1) (order this), DKEY-166D12 (1) (order this)
    padi2 Encodes: [EST] cb968 (1) (order this), IMAGE:6903054 (1), IMAGE:7158214 (1)
    [cDNA] MGC:66317 (1), MGC:192723 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200112 (1) 2431 bp
    Genomic GenBank:CR391948 (1) 149996 bp
    Select Tool
    Polypeptide UniProtKB:F1QTZ4 (1) 647 aa
    Sequence Information (all 21)
    ORTHOLOGY for padi2 ( Chr: 6 )
    CITATIONS (24)