ZFIN ID: ZDB-GENE-031116-61
Gene Name: atypical chemokine receptor 3b
Gene Symbol: ackr3b    Nomenclature History

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Previous Names: CXCR7 (1), cxcr7b (1), drRDC1b (1), sb:cb900, si:dkey-96h14.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Exhibits chemokine binding activity. Involved in several processes, including blood vessel morphogenesis; nervous system development; and posterior lateral line neuromast primordium migration. Predicted to localize to external side of plasma membrane. Is expressed in several structures, including anterior neural keel; hindbrain neural keel; immature eye; nervous system; and neural rod. Orthologous to human ACKR3 (atypical chemokine receptor 3).
Genome Resources: Alliance (1),  Gene:561050 (1),  Ensembl(GRCz11):ENSDARG00000058179 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11907 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ackr3b N/A 1
    MO2-ackr3b N/A 1
    MO3-ackr3b N/A 10
    MO4-ackr3b N/A 2
    MO5-ackr3b N/A 3
    MO6-ackr3b N/A 5
    MO7-ackr3b N/A 1
    MO8-ackr3b N/A 1
    MO9-ackr3b N/A 1
    DISEASE ASSOCIATED WITH ackr3b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ackr3b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chemotaxis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function chemokine binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ackr3b-201 (1)    Ensembl 1953
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-ackr3b monoclonal Mouse IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ackr3b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(6xUAS:ackr3b-GFP) UAS ackr3bGFPT2M Danio rerio 1 2
    Tg(hsp70l:ackr3b) hsp70l ackr3b Danio rerio 1 3
    Tg(tubb2b:ackr3b-IRES-Cerulean-CAAX) tubb2b ackr3bCerulean Danio rerio 1 3
    MARKER RELATIONSHIPS
    ackr3b Contained in: [BAC] DKEY-96H14 (1) (order this)
    ackr3b Encodes: [EST] cb900 (1) (order this)
    [cDNA] MGC:162246 (1), MGC:174173 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001083832 (1) 1965 nt
    Genomic GenBank:BX784037 (1) 126572 nt
    Select Tool
    Polypeptide UniProtKB:A4IG54 (1) 362 aa
    Sequence Information (all 16)
    ORTHOLOGY for ackr3b ( Chr: 6 )
    CITATIONS (80)