ZFIN ID: ZDB-GENE-031112-11
Gene Name: flap structure-specific endonuclease 1
Gene Symbol: fen1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: cb879 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have metal ion binding activity and nuclease activity. Involved in retina development in camera-type eye. Predicted to localize to nucleus. Is expressed in brain; head; pectoral fin musculature; and proliferative region. Orthologous to human FEN1 (flap structure-specific endonuclease 1).
Genome Resources: Alliance (1),  Gene:386707 (1),  Ensembl(GRCz11):ENSDARG00000011404 (2)
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Directly Submitted Expression Data: 6 figures (6 images) from Thisse et al., 2001 [cb879]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi4026Tg Transgenic Insertion Exon 3 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15638 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24456 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32479 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37839 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-fen1 N/A 1
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH fen1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH fen1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process retina development in camera-type eye (more)
    Cellular Component mitochondrion (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 24)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fen1 No data available
    MARKER RELATIONSHIPS
    fen1 Encodes: [EST] cb879 (1) (order this)
    [cDNA] MGC:56370 (1), MGC:86842 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001328507 (1)
    Genomic GenBank:CABZ01101621 (1) 4816 nt
    Polypeptide UniProtKB:Q6TNU4 (1) 380 aa
    Sequence Information (all 26)
    ORTHOLOGY for fen1 ( Chr: 24 )
    CITATIONS (41)