ZFIN is now using GRCz12tu for Genomic Data
Gene
tardbpa
- ID
- ZDB-GENE-031030-1
- Name
- TAR DNA binding protein a
- Symbol
- tardbpa Nomenclature History
- Previous Names
-
- tardbp
- tardbpl
- wu:fb52e05
- wu:fe47c11
- wu:fj94b04
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable RNA binding activity. Acts upstream of or within several processes, including axon extension; neuromuscular junction development; and skeletal muscle tissue development. Predicted to be located in mitochondrion and nucleus. Predicted to be active in chromatin and nucleoplasm. Is expressed in brain and fin. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Orthologous to human TARDBP (TAR DNA binding protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55467 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 10 | Alliance | Amyotrophic lateral sclerosis 10, with or without FTD | 612069 |
| amyotrophic lateral sclerosis type 10 | Alliance | Frontotemporal lobar degeneration, TARDBP-related | 612069 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR041105 | TAR DNA-binding protein 43, N-terminal |
| Domain | IPR049124 | TAR DNA-binding protein 43, C-terminal |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain | TAR DNA-binding protein 43, C-terminal | TAR DNA-binding protein 43, N-terminal |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q803N5 | InterPro | 303 | |||||
| UniProtKB:A0A8M9PSZ1 | InterPro | 396 | |||||
| UniProtKB:A0AB13A8U5 | InterPro | 298 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
tardbpl-201
(1)
|
Ensembl | 1,785 nt | ||
| aberrant processed transcript |
tardbpl-202
(1)
|
Ensembl | 2,244 nt | ||
| mRNA |
tardbpl-203
(1)
|
Ensembl | 1,828 nt | ||
| mRNA |
tardbpl-204
(1)
|
Ensembl | 1,773 nt | ||
| mRNA |
tardbpl-205
(1)
|
Ensembl | 941 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-tardbpl | monoclonal | IgG2a | Rat |
|
1 | ||
| Ab2-tardbpl | monoclonal | IgG2c | Rat |
|
1 | ||
| Ab3-tardbpl | monoclonal | IgG2a | Rat |
|
2 |
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Hewamadduma, et al. (2013. Human molecular genetics 22:2376-86.) suggested this gene was the ortholog of human TARDBPP1 and mouse GM13886 based on conserved location. Subsequent data and analysis supports it being the ortholog of human TARDBP and mouse Tardbp.