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ZIRC
ZFIN ID: ZDB-GENE-031030-1
Gene Name: TAR DNA binding protein, like
Gene Symbol: tardbpl    Nomenclature History

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Previous Names: tardbp, wu:fb52e05, wu:fe47c11, wu:fj94b04

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have double-stranded DNA binding activity; mRNA 3'-UTR binding activity; and single-stranded RNA binding activity. Involved in several processes, including axon extension; neuromuscular junction development; and skeletal muscle tissue development. Predicted to localize to the cytoplasm; nucleoplasm; and ribonucleoprotein complex. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Is expressed in brain and fin. Orthologous to several human genes including TARDBP (TAR DNA binding protein).
Genome Resources: Alliance (1),  Gene:386630 (1),  Ensembl(GRCz11):ENSDARG00000004452 (1)
GENE EXPRESSION
All Expression Data: 7 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55467]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mde114 Small Deletion Exon 1 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
mde159 Small Deletion Exon 1 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
mde222 Small Deletion Exon 1 Unknown ZINC_FINGER_NUCLEASE
sa39415 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • udm104 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tardbpl
    1
    CRISPR2-tardbpl 1
    MO1-tardbpl N/A 3
    DISEASE ASSOCIATED WITH tardbpl HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tardbpl VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon extension (more)
    Cellular Component nucleoplasm (more)
    Molecular Function nucleic acid binding (more)
    GO Terms (all 14)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript tardbpl-201 (1)    Ensembl 1785
    tardbpl-202 (1)    Ensembl 2244
    mRNA tardbpl-203 (1)    Ensembl 1828
    tardbpl-204 (1)    Ensembl 1773
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-tardbpl monoclonal IgG2a Rat WB 1
    Ab2-tardbpl monoclonal IgG2c Rat 1
    Ab3-tardbpl monoclonal IgG2a Rat WB 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tardbpl No data available
    MARKER RELATIONSHIPS
    tardbpl Contained in: [BAC] CH211-129O18 (1) (order this)
    tardbpl Encodes: [EST] fb52e05, fe47c11, fj94b04
    [cDNA] MGC:55467 (1) (order this), MGC:77290 (1) (order this), MGC:191428 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_198364 (1) 1797 bp
    Genomic GenBank:CR381616 (1) 89029 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8QEL5 (1) 402 aa
    Sequence Clusters UniGene:33664 (1)
    Sequence Information (all 36)
    ORTHOLOGY for tardbpl ( Chr: 23 )
    CITATIONS (29)