Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-031010-21
Gene Name: fibrinogen alpha chain
Gene Symbol: fga
Previous Names: sb:cb892, wu:fa55c12, wu:fb20e08, wu:fb59b03, wu:fi39d04, zgc:92117
Location: Chr: 1   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 10 figures from 4 publications
Directly Submitted Expression Data: 5 figures (5 images) from Thisse et al., 2001 [cb892]
Wild-type Stages, Structures: Segmentation:10-13 somites (14.0h-16.0h) to Adult (90d-730d, breeding adult)
  liver, whole organism, YSL
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: sa12469
Knockdown reagents: MO1-fga (1)
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Afibrinogenemia, congenital 202400
Amyloidosis, hereditary renal 105200
Dysfibrinogenemia, alpha type, causing bleeding diathesis
Dysfibrinogenemia, alpha type, causing recurrent thrombosis
GENE ONTOLOGY
Ontology GO Term
Biological Process blood coagulation, fibrin clot formation (more)
Cellular Component fibrinogen complex (more)
Molecular Function protein binding, bridging (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002181 (1)
  • InterPro:IPR012290 (1)
  • InterPro:IPR014715 (1)
  • InterPro:IPR014716 (1)
  • InterPro:IPR020837 (1)
  • InterPro:IPR021996 (1)
  • PROSITE:PS00514 (1)
  • PROSITE:PS51406 (1)
  • Pfam:PF00147 (1)
  • Pfam:PF08702 (1)
  • Pfam:PF12160 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA fga-001 (1) 2366
    fga-002 (1) 2469
    ncRNA fga-003 (1) 690
    fga-004 (1) 768
    fga-005 (1) 751
    fga-006 (1) 503
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM fga No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    fga Contained in: [BAC] DKEYP-75B4 (1)
    fga Encodes: [EST] cb892 (1) (order this), fa55c12, fb20e08, fb59b03, fi39d04
    [cDNA] MGC:92117 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001194989 (1) 2349 bp
    Genomic GenBank:BX548256 (1) 181272 bp
    Select Tool
    Polypeptide UniProtKB:B8A5L6 (1) 684 aa
    Sequence Clusters UniGene:33271 (1)
    Sequence Information (all 23)
    OTHER fga GENE PAGES
  • Gene:378986 (1)
  • VEGA:OTTDARG00000019537 (1)
  • Ensembl(Zv9):ENSDARG00000020741 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish fga 1  
    Human FGA 4 (4q28)
  • OMIM:134820
  • Gene:2243
  • Mouse Fga 3 ( 36.96 cM)
  • MGI:1316726
  • Gene:14161
  • Orthology Details
    CITATIONS (21)