ZFIN ID: ZDB-GENE-031009-1
Gene Name: fascin actin-bundling protein 1a
Gene Symbol: fscn1a    Nomenclature History

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Previous Names: fscn1, sb:cb589, zgc:153632

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Exhibits actin filament binding activity; protein-macromolecule adaptor activity; and signaling receptor binding activity. Involved in several processes, including animal organ development; epiboly; and pharyngeal system development. Predicted to localize to several cellular components, including lamellipodium; microvillus; and ruffle. Is expressed in several structures, including head; mesoderm; nervous system; neural crest; and neural plate. Orthologous to human FSCN1 (fascin actin-bundling protein 1).
Genome Resources: Alliance (1),  Gene:558271 (1),  Ensembl(GRCz11):ENSDARG00000059680 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ioz6 Indel Unknown Unknown CRISPR
ioz100 Indel Exon 1 Frameshift, Premature Stop TALEN
  • China Zebrafish Resource Center (CZRC) (order this)
  • la024199Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44571 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • zd1011 Small Deletion Exon 1 Frameshift, Premature Stop TALEN
    zd1012 Small Deletion Exon 1 Frameshift, Premature Stop TALEN
    zd1013 Indel Unknown Frameshift, Premature Stop TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-fscn1a
    3
    CRISPR2-fscn1a
    1
    CRISPR3-fscn1a
    1
    MO1-fscn1a N/A 2
    MO2-fscn1a N/A 1
    MO3-fscn1a N/A 1
    TALEN1-fscn1a 1
    TALEN2-fscn1a 1
    DISEASE ASSOCIATED WITH fscn1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH fscn1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic viscerocranium morphogenesis (more)
    Cellular Component cytoplasm (more)
    Molecular Function actin binding (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fscn1a-201 (1)    Ensembl 3077
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-fscn1 monoclonal IgG Rabbit IHC Epitomics, Inc
    3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fscn1a No data available
    MARKER RELATIONSHIPS
    fscn1a Contained in: [BAC] CH211-255L18 (1)
    fscn1a Encodes: [EST] cb589 (1) (order this), wz2126 (1)
    [cDNA] MGC:153632 (1), MGC:192701 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001076560 (1) 2495 nt
    Genomic GenBank:AL929031 (1) 187548 nt
    Select Tool
    Polypeptide UniProtKB:F1QET7 (1) 491 aa
    Sequence Information (all 16)
    ORTHOLOGY for fscn1a ( Chr: 3 )
    CITATIONS (42)