ZFIN ID: ZDB-GENE-031006-7
Gene Name: SLC9A3 regulator 1a
Gene Symbol: slc9a3r1a    Nomenclature History

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Previous Names: cb895 (1), nherf1 (1), slc9a3 (1), slc9a3r1, slc9a3r2, wu:fd20a02, zgc:55541, zgc:77629

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have molecular adaptor activity. Involved in several processes, including otic vesicle development; protein localization to membrane; and sodium ion homeostasis. Predicted to localize to endomembrane system and membrane. Is expressed in several structures, including anterior neural keel; central nervous system; mesoderm; neural tube; and pronephros. Used to study ciliopathy. Human ortholog(s) of this gene implicated in hypophosphatemic nephrolithiasis/osteoporosis 2. Orthologous to human SLC9A3R1 (SLC9A3 regulator 1).
Genome Resources: Alliance (1),  Gene:327272 (1),  Ensembl(GRCz11):ENSDARG00000000068 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018224Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-slc9a3r1a
    1
    MO1-slc9a3r1a N/A 2
    MO2-slc9a3r1a N/A 1
    DISEASE ASSOCIATED WITH slc9a3r1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hypophosphatemic nephrolithiasis/osteoporosis 2 Alliance Nephrolithiasis/osteoporosis, hypophosphatemic, 2 612287
    DISEASE ASSOCIATED WITH slc9a3r1a VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    ciliopathy AB + MO2-slc9a3r1a standard conditions Treat et al., 2016
    AB + MO1-slc9a3r1a standard conditions Treat et al., 2016
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein targeting to membrane (more)
    Cellular Component cell projection (more)
    Molecular Function molecular adaptor activity (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA slc9a3r1a-201 (1)    Ensembl 2033
    ncRNA slc9a3r1-002 (1)    Ensembl 901
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slc9a3r1a No data available
    MARKER RELATIONSHIPS
    slc9a3r1a Contained in: [BAC] CH211-13L14 (1)
    slc9a3r1a Contains: [STS] chunp30607
    slc9a3r1a Encodes: [EST] cb895 (1) (order this), fd20a02 (1)
    [cDNA] MGC:55541 (1), MGC:77629 (1), MGC:191987 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212707 (1) 2072 nt
    Genomic GenBank:CR735103 (1) 126042 nt
    Select Tool
    Polypeptide UniProtKB:Q7ZVX1 (1) 386 aa
    Sequence Information (all 22)
    ORTHOLOGY for slc9a3r1a ( Chr: 12 )
    CITATIONS (32)