ZFIN ID: ZDB-GENE-031006-12
Gene Name: ATP-binding cassette, sub-family A (ABC1), member 1A
Gene Symbol: abca1a    Nomenclature History

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Previous Names: abca1, cb939 (1), fa03d03, im:6795541, wu:fa03d03, wu:fj13h01

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have ATPase-coupled transmembrane transporter activity and lipid transporter activity. Involved in regulation of cholesterol efflux and sprouting angiogenesis. Predicted to localize to the intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hypolipoproteinemia (multiple); obesity; and type 2 diabetes mellitus. Is expressed in several structures, including blood vessel; central nervous system; neural tube; pleuroperitoneal region; and segmental plate. Orthologous to human ABCA1 (ATP binding cassette subfamily A member 1).
Genome Resources: Alliance (1),  Gene:558924 (1),  Ensembl(GRCz11):ENSDARG00000074635 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa928 Point Mutation Unknown Splice Site ENU
sa2010 Point Mutation Unknown Splice Site ENU
sa5800 Point Mutation Unknown Splice Site ENU
sa9624 Point Mutation Intron 29 Splice Site, Cryptic Acceptor Splice Site, Exon Loss ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12376 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13007 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15548 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa32775 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39699 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko1040a Insertion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-abca1a 1
    MO1-abca1a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH abca1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Tangier disease Alliance Tangier disease 205400
    HDL deficiency, familial, 1 604091
    DISEASE ASSOCIATED WITH abca1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of cholesterol efflux (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATPase activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR003439 ABC transporter-like
    Domain IPR003593 AAA+ ATPase domain
    Conserved_site IPR017871 ABC transporter, conserved site
    Family IPR026082 ABC transporter A
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA abca1a-202 (1)    Ensembl 9428
    ncRNA abca1a-002 (1)    Ensembl 697
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM abca1a No data available
    MARKER RELATIONSHIPS
    abca1a Contained in: [BAC] CH211-149G8 (1)
    abca1a Encodes: [EST] cb939 (1) (order this), fa03d03, fj13h01, IMAGE:6795541
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001309465 (1)
    Genomic GenBank:BX004781 (1) 169991 bp
    Select Tool
    Polypeptide UniProtKB:B8A446 (1) 2268 aa
    Sequence Information (all 15)
    ORTHOLOGY for abca1a ( Chr: 1 )
    CITATIONS (33)