ZFIN ID: ZDB-GENE-031006-1
Gene Name: isocitrate dehydrogenase (NADP(+)) 1
Gene Symbol: idh1    Nomenclature History

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Previous Names: cb876 (1), fm90e09, im:7143416, wu:fm90e09 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have isocitrate dehydrogenase (NADP+) activity. Involved in hemopoiesis. Predicted to localize to cytosol; mitochondrion; and peroxisome. Is expressed in several structures, including digestive system; ectoderm; mesoderm; nervous system; and pronephric duct. Human ortholog(s) of this gene implicated in acute myeloid leukemia; glioblastoma multiforme; hepatocellular clear cell carcinoma; malignant glioma; and myelodysplastic syndrome. Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1).
Genome Resources: Alliance (1),  Gene:100006589 (1),  Ensembl(GRCz11):ENSDARG00000025375 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010378Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la026869Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la026870Tg Transgenic Insertion Unknown Unknown DNA
    la029573Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-idh1
    1
    MO1-idh1 N/A 1
    TALEN1-idh1
    1
    TALEN2-idh1
    1
    TALEN3-idh1
    1
    DISEASE ASSOCIATED WITH idh1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Glioma, susceptibility to, somatic} 137800
    DISEASE ASSOCIATED WITH idh1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hemopoiesis (more)
    Cellular Component cytosol (more)
    Molecular Function isocitrate dehydrogenase (NADP+) activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM idh1 No data available
    MARKER RELATIONSHIPS
    idh1 Contained in: [BAC] CH211-11O22 (1), DKEY-159B16 (1) (order this)
    idh1 Contains: [SNP] rs3727712, rs3727713
    idh1 Encodes: [EST] cb876 (1) (order this), fm90e09, IMAGE:7143416 (1)
    [STS] chunp30652
    [cDNA] MGC:55806 (1), MGC:171441 (1), MGC:174090 (1), MGC:192657 (1)
    idh1 Has Artifact: [EST] fb63c12
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201499 (1) 2024 nt
    Genomic GenBank:CR376856 (1) 179053 nt
    Select Tool
    Polypeptide UniProtKB:B0UXL2 (1) 429 aa
    Sequence Information (all 38)
    ORTHOLOGY for idh1 ( Chr: 9 )
    CITATIONS (41)