Gene

tln1

ID
ZDB-GENE-031002-48
Name
talin 1
Symbol
tln1 Nomenclature History
Previous Names
  • sb:cb854
  • wu:fb05c02
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have integrin binding activity. Involved in animal organ development and sarcomere organization. Predicted to localize to focal adhesion and plasma membrane. Is expressed in several structures, including adaxial cell; cardiovascular system; cranium; musculature system; and nervous system. Orthologous to human TLN1 (talin 1).
Genome Resources
Note
None
Expression
All Expression Data
13 figures from 6 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tln1 Human Ortholog
No data available
Associated With tln1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019747 FERM conserved site
Domain IPR000299 FERM domain
Domain IPR002404 IRS-type PTB domain
Domain IPR002558 I/LWEQ domain
Domain IPR015009 Vinculin-binding site-containing domain
Domain IPR015224 Talin, central
Domain IPR018979 FERM, N-terminal
Domain IPR019748 FERM central domain
Domain IPR019749 Band 4.1 domain
Domain IPR032425 Talin, N-terminal F0 domain
Domain IPR037438 Talin-1/2, rod-segment
Family IPR030224 Sla2 family
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR014352 FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Homologous_superfamily IPR035963 FERM superfamily, second domain
Homologous_superfamily IPR035964 I/LWEQ domain superfamily
Homologous_superfamily IPR036476 Talin, central domain superfamily
Homologous_superfamily IPR036723 Alpha-catenin/vinculin-like superfamily
Domain Details Per Protein
Protein Length Alpha-catenin/vinculin-like superfamily Band 4.1 domain FERM/acyl-CoA-binding protein superfamily FERM central domain FERM conserved site FERM domain FERM, N-terminal FERM superfamily, second domain I/LWEQ domain I/LWEQ domain superfamily IRS-type PTB domain PH-like domain superfamily Sla2 family Talin-1/2, rod-segment Talin, central Talin, central domain superfamily Talin, N-terminal F0 domain Ubiquitin-like domain superfamily Vinculin-binding site-containing domain
UniProtKB:A0A0R4IDZ8 2544
UniProtKB:Q0V946 405
UniProtKB:A1L1Z3 323
UniProtKB:Q6DEN1 294
UniProtKB:Q5U7N6 2538
UniProtKB:Q568S4 321
UniProtKB:A3KP11 112
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-tln1 polyclonal
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations