ZFIN ID: ZDB-GENE-031002-48
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Gene Name: talin 1
Gene Symbol: tln1    Nomenclature History

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Previous Names: sb:cb854, wu:fb05c02

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity and clathrin binding activity. Involved in animal organ development and sarcomere organization. Predicted to localize to the cytoskeleton; focal adhesion; and ruffle. Is expressed in several structures, including adaxial cell; cardiovascular system; cranium; musculature system; and nervous system. Orthologous to human TLN1 (talin 1).
Genome Resources: Alliance (1),  Gene:494453 (1),  Ensembl(GRCz11):ENSDARG00000100729 (1)
GENE EXPRESSION
All Expression Data: 13 figures from 6 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2001 [cb854]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
f102k Point Mutation Donor Splice Site of Intron 9 Splice Site, Intron Gain of Intron 9, Premature Stop ENU
hi3093Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa2572 Point Mutation Unknown Splice Site ENU
    sa5825 Point Mutation Unknown Splice Site ENU
    sa6161 Point Mutation Unknown Premature Stop ENU
    sa10075 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa11348 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa15487 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa21664 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa21665 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa21666 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa31764 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa34845 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa34846 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa38777 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa41593 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tln1
    		1
    MO1-tln1 N/A 1
    MO2-tln1 N/A 1
    PHENOTYPE
    Data: 14 figures from 5 publications
    Observed in:
    DISEASE ASSOCIATED WITH tln1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tln1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cardiac muscle cell development (more)
    Cellular Component cytoskeleton (more)
    Molecular Function actin binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000299 FERM domain
    Domain IPR002404 IRS-type PTB domain
    Domain IPR002558 I/LWEQ domain
    Homologous_superfamily IPR011993 PH-like domain superfamily
    Homologous_superfamily IPR014352 FERM/acyl-CoA-binding protein superfamily
    Domain IPR015009 Vinculin-binding site-containing domain
    Domain IPR015224 Talin, central
    Domain IPR018979 FERM, N-terminal
    Conserved_site IPR019747 FERM conserved site
    Domain IPR019748 FERM central domain
    Domain IPR019749 Band 4.1 domain
    Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
    Family IPR030224 Sla2 family
    Domain IPR032425 Talin, N-terminal F0 domain
    Homologous_superfamily IPR035963 FERM superfamily, second domain
    Homologous_superfamily IPR035964 I/LWEQ domain superfamily
    Homologous_superfamily IPR036476 Talin, central domain superfamily
    Homologous_superfamily IPR036723 Alpha-catenin/vinculin-like superfamily
    Domain IPR037438 Talin-1/2, rod-segment
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tln1-201 (1)    Ensembl 8746
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-tln1 polyclonal IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tln1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(myl7:tln1-EGFP) myl7 EGFP,  tln1 Danio rerio 1 1
    Tg2(myl7:tln1-EGFP) myl7 EGFP,  tln1 Danio rerio 1 1
    MARKER RELATIONSHIPS
    tln1 Contained in: [BAC] DKEY-30O2 (1) (order this), DKEY-42J10 (1) (order this)
    tln1 Contains: [STS] chunp30554
    tln1 Encodes: [EST] cb854 (1) (order this), fb05c02
    [cDNA] MGC:162832 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001009560 (1) 7938 bp
    Select Tool
    Genomic GenBank:BX323809 (1) 194108 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IDZ8 (1) 2544 aa
    Select Tool
    Sequence Information (all 38)
    ORTHOLOGY for tln1 ( Chr: 10 )
    CITATIONS (33)