Gene

tln1

ID

ZDB-GENE-031002-48

Name

talin 1

Symbol

tln1 Nomenclature History

Previous Names

sb:cb854
wu:fb05c02

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Is predicted to enable integrin binding activity. Involved in cell-cell adhesion. Acts upstream of or within animal organ development and sarcomere organization. Predicted to be located in several cellular components, including cytoplasm; cytoskeleton; and ruffle. Is expressed in several structures, including adaxial cell; cardiovascular system; cranium; musculature system; and nervous system. Orthologous to human TLN1 (talin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb854 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tln1 Human Ortholog

No data available

Associated With tln1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019747	FERM conserved site
Domain	IPR000299	FERM domain
Domain	IPR002404	IRS-type PTB domain
Domain	IPR002558	I/LWEQ domain
Domain	IPR015009	Vinculin-binding site-containing domain
Domain	IPR015224	Talin, central
Domain	IPR018979	FERM, N-terminal
Domain	IPR019748	FERM central domain
Domain	IPR019749	Band 4.1 domain
Domain	IPR032425	Talin, N-terminal F0 domain
Domain	IPR037438	Talin-1/2, rod-segment
Family	IPR030224	Sla2 family
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR014352	FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035963	FERM superfamily, second domain
Homologous_superfamily	IPR035964	I/LWEQ domain superfamily
Homologous_superfamily	IPR036476	Talin, central domain superfamily
Homologous_superfamily	IPR036723	Alpha-catenin/vinculin-like superfamily

Domain Details Per Protein

Protein	Length	Alpha-catenin/vinculin-like superfamily	Band 4.1 domain	FERM/acyl-CoA-binding protein superfamily	FERM central domain	FERM conserved site	FERM domain	FERM, N-terminal	FERM superfamily, second domain	I/LWEQ domain	I/LWEQ domain superfamily	IRS-type PTB domain	PH-like domain superfamily	Sla2 family	Talin-1/2, rod-segment	Talin, central	Talin, central domain superfamily	Talin, N-terminal F0 domain	Ubiquitin-like domain superfamily	Vinculin-binding site-containing domain
UniProtKB:Q0V946 InterPro	405
UniProtKB:A1L1Z3 InterPro	323
UniProtKB:A3KP11 InterPro	112
UniProtKB:A0A0R4IDZ8 InterPro	2544
UniProtKB:Q5U7N6 InterPro	2538
UniProtKB:Q6DEN1 InterPro	294
UniProtKB:Q568S4 InterPro	321