ZFIN ID: ZDB-GENE-030912-7
Gene Name: transient receptor potential cation channel, subfamily V, member 4
Gene Symbol: trpv4
Sequence Ontology ID : SO:0000704

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Previous Name: wu:fp52e02

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(Including Attributions)
Location: Chr: 5 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have calcium channel activity; involved in atrioventricular valve development, cellular response to oscillatory fluid shear stress, and response to osmotic stress; predicted to localize  ...
GENE EXPRESSION
All Expression Data: 16 figures from 6 publications
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa84 Point Mutation Unknown Unknown ENU
sa1671 Point Mutation Exon 12 Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15329 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26435 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 4 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH trpv4 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    brachyolmia Brachyolmia type 3 113500
    Charcot-Marie-Tooth disease axonal type 2C Hereditary motor and sensory neuropathy, type IIc 606071
    ?Avascular necrosis of femoral head, primary, 2 617383
    Digital arthropathy-brachydactyly, familial 606835
    Spinal muscular atrophy, distal, congenital nonprogressive 600175
    SED, Maroteaux type 184095
    Parastremmatic dwarfism 168400
    [Sodium serum level QTL 1] 613508
    Scapuloperoneal spinal muscular atrophy 181405
    Metatropic dysplasia 156530
    Spondylometaphyseal dysplasia, Kozlowski type 184252
    DISEASE ASSOCIATED WITH trpv4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process atrioventricular valve development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ion channel activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002110 (1)
  • InterPro:IPR005821 (1)
  • InterPro:IPR008347 (1)
  • InterPro:IPR008348 (1)
  • InterPro:IPR020683 (1)
  • InterPro:IPR024862 (1)
  • InterPro:IPR036770 (1)
  • PROSITE:PS50088 (1)
  • PROSITE:PS50297 (1)
  • Pfam:PF00023 (1)
  • Pfam:PF00520 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA trpv4-001 (1) 2741
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM trpv4 No data available
    MARKER RELATIONSHIPS
    trpv4Contained in: [BAC] DKEY-234H16 (1) (order this)
    trpv4Encodes: [EST] fp52e02 (1)
    [cDNA] MGC:195087 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001042730 (1) 2628bp
    Genomic GenBank:BX323811 (1) 204094bp Blast at MegaBLAST
    Polypeptide UniProtKB:A2BG42 (1) 856aa
    Sequence Clusters UniGene:85921 (1)
    Sequence Information (all 20)
    OTHER trpv4 GENE PAGES
  • Alliance (1)
  • Gene:557850 (1)
  • VEGA:OTTDARG00000016055 (1)
  • Ensembl(GRCz11):ENSDARG00000061941 (2)
  • ORTHOLOGY for trpv4 (Chr: 5)
    CITATIONS (40)