ZFIN ID: ZDB-GENE-030909-9
Gene Name: glutamate decarboxylase 2
Gene Symbol: gad2    Nomenclature History

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Previous Names: GAD65 (1), gad65 (1), zgc:112198

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have glutamate decarboxylase activity and pyridoxal phosphate binding activity. Involved in gamma-aminobutyric acid biosynthetic process. Is expressed in central nervous system; eye; and neurons. Human ortholog(s) of this gene implicated in gestational diabetes; schizophrenia; and type 1 diabetes mellitus. Orthologous to human GAD2 (glutamate decarboxylase 2).
Genome Resources: Alliance (1),  Gene:550403 (1),  Ensembl(GRCz11):ENSDARG00000015537 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la023079Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la023080Tg Transgenic Insertion Unknown Unknown DNA
    sa30034 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37819 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-gad2 N/A 1
    MO2-gad2 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gad2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH gad2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process gamma-aminobutyric acid biosynthetic process (more)
    Cellular Component cellular_component (more)
    Molecular Function carboxy-lyase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gad2-201 (1)    Ensembl 6409
    ncRNA gad2-002 (1)    Ensembl 511
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-gad2 polyclonal Rabbit IHC, WB Millipore
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gad2 No data available
    MARKER RELATIONSHIPS
    gad2 Contained in: [BAC] CH211-37E10 (1), DKEY-48C13 (1) (order this)
    gad2 Encodes: [cDNA] MGC:112198 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001017708 (1) 6411 nt
    Genomic GenBank:BX530066 (1) 202859 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1R9E8 (1) 583 aa
    Sequence Information (all 16)
    ORTHOLOGY for gad2 ( Chr: 24 )
    CITATIONS (73)