Gene

gad2

ID
ZDB-GENE-030909-9
Name
glutamate decarboxylase 2
Symbol
gad2 Nomenclature History
Previous Names
  • GAD65 (1)
  • gad65 (1)
  • zgc:112198
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to have glutamate decarboxylase activity and pyridoxal phosphate binding activity. Involved in gamma-aminobutyric acid biosynthetic process and neurotransmitter biosynthetic process. Is expressed in central nervous system; eye; and neurons. Human ortholog(s) of this gene implicated in gestational diabetes; schizophrenia; and type 1 diabetes mellitus. Orthologous to human GAD2 (glutamate decarboxylase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
35 figures from 20 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from O'Connor et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gad2 Human Ortholog
No data available
Associated With gad2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR021115 Pyridoxal-phosphate binding site
Family IPR002129 Pyridoxal phosphate-dependent decarboxylase
Homologous_superfamily IPR015421 Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily IPR015424 Pyridoxal phosphate-dependent transferase
Domain Details Per Protein
Protein Length Pyridoxal-phosphate binding site Pyridoxal phosphate-dependent decarboxylase Pyridoxal phosphate-dependent transferase Pyridoxal phosphate-dependent transferase, major domain
UniProtKB:O93275 232
UniProtKB:Q567A0 187
UniProtKB:F1R9E8 583
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-gad2 polyclonal Rabbit
  • IHC
  • WB
Millipore
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations