Gene

add1

ID
ZDB-GENE-030909-2
Name
adducin 1 (alpha)
Symbol
add1 Nomenclature History
Previous Names
  • cb787 (1)
  • zgc:158352
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to enable actin filament binding activity. Predicted to be involved in barbed-end actin filament capping; positive regulation of adherens junction organization; and positive regulation of establishment of endothelial barrier. Predicted to be active in several cellular components, including adherens junction; cytoskeleton; and postsynaptic density. Is expressed in nervous system and pronephric duct. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; and gastroschisis. Orthologous to human ADD1 (adducin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
17 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With add1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
essential hypertension Alliance {Hypertension, essential, salt-sensitive} 145500
Associated With add1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001303 Class II aldolase/adducin N-terminal
Family IPR027766 Alpha-adducin
Homologous_superfamily IPR036409 Class II aldolase/adducin N-terminal domain superfamily
Domain Details Per Protein
Protein Length Alpha-adducin Class II aldolase/adducin N-terminal Class II aldolase/adducin N-terminal domain superfamily
UniProtKB:A1A5X4 741
UniProtKB:A0A0R4IT10 608
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations