Gene

add1

ID
ZDB-GENE-030909-2
Name
adducin 1 (alpha)
Symbol
add1 Nomenclature History
Previous Names
  • cb787 (1)
  • zgc:158352
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have actin filament binding activity; spectrin binding activity; and structural molecule activity. Predicted to be involved in several processes, including barbed-end actin filament capping; positive regulation of adherens junction organization; and positive regulation of establishment of endothelial barrier. Predicted to localize to several cellular components, including adherens junction; plasma membrane raft; and postsynaptic density. Is expressed in nervous system and pronephric duct. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; and gastroschisis. Orthologous to human ADD1 (adducin 1).
Genome Resources
Note
None
Expression
All Expression Data
17 figures from 3 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With add1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
essential hypertension Alliance {Hypertension, essential, salt-sensitive} 145500
Associated With add1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001303 Class II aldolase/adducin N-terminal
Family IPR027766 Alpha-adducin
Homologous_superfamily IPR036409 Class II aldolase/adducin N-terminal domain superfamily
Domain Details Per Protein
Protein Length Alpha-adducin Class II aldolase/adducin N-terminal Class II aldolase/adducin N-terminal domain superfamily
UniProtKB:A0A0R4IT10 608
UniProtKB:A1A5X4 741
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations