ZFIN ID: ZDB-GENE-030909-2
Gene Name: adducin 1 (alpha)
Gene Symbol: add1    Nomenclature History

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Previous Names: cb787 (1), zgc:158352

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity; spectrin binding activity; and structural molecule activity. Predicted to be involved in several processes, including barbed-end actin filament capping; positive regulation of adherens junction organization; and positive regulation of establishment of endothelial barrier. Predicted to localize to several cellular components, including adherens junction; plasma membrane raft; and postsynaptic density. Is expressed in nervous system and pronephric duct. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; and gastroschisis. Orthologous to human ADD1 (adducin 1).
Genome Resources: Alliance (1),  Gene:555511 (1),  Ensembl(GRCz11):ENSDARG00000103962 (1)
GENE EXPRESSION
All Expression Data: 17 figures from 3 publications
Directly Submitted Expression Data: 4 figures (8 images) from Thisse et al., 2001 [cb787]
  12 figures (25 images) from Rauch et al., 2003 [fu40b10]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la021946Tg Transgenic Insertion Unknown Unknown DNA
sa9003 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9196 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37206 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH add1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    essential hypertension Alliance {Hypertension, essential, salt-sensitive} 145500
    DISEASE ASSOCIATED WITH add1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process actin filament bundle assembly (more)
    Cellular Component cytoskeleton (more)
    Molecular Function actin filament binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA add1-201 (1)    Ensembl 1834
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM add1 No data available
    MARKER RELATIONSHIPS
    add1 Contained in: [BAC] RP71-1H20
    add1 Encodes: [EST] cb787 (1) (order this), fu40b10 (1) (order this)
    [cDNA] MGC:158352 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001079958 (1) 2984 nt
    Genomic GenBank:AL627305 (1) 150276 nt
    Select Tool
    Polypeptide UniProtKB:A1A5X4 (1) 741 aa
    Sequence Information (all 32)
    ORTHOLOGY for add1 ( Chr: 21 )
    CITATIONS (28)