ZFIN ID: ZDB-GENE-030903-5
Gene Name: FYN proto-oncogene, Src family tyrosine kinase a
Gene Symbol: fyna    Nomenclature History

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Previous Names: fyn, zgc:86720

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Exhibits protein kinase activity. Involved in several processes, including adherens junction maintenance; gastrulation; and protein autophosphorylation. Localizes to cytosol and nucleus. Is expressed in central nervous system; olfactory placode; peripheral olfactory organ; and retina. Human ortholog(s) of this gene implicated in Alzheimer's disease and schizophrenia. Orthologous to human FYN (FYN proto-oncogene, Src family tyrosine kinase).
Genome Resources: Alliance (1),  Gene:373872 (1),  Ensembl(GRCz11):ENSDARG00000011370 (2)
GENE EXPRESSION
All Expression Data: 9 figures from 6 publications
Directly Submitted Expression Data: 4 figures (6 images) from Thisse et al., 2004 [IMAGE:6897140]
Wild-type Stages, Structures: Cleavage:8-cell (1.25h-1.5h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu2570 Point Mutation Unknown Unknown ENU
sa14225 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36363 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36364 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42896 Point Mutation Unknown Missense, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-fyna
    1
    CRISPR2-fyna
    1
    MO1-fyna,fynb N/A 7
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH fyna HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH fyna VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein autophosphorylation (more)
    Cellular Component cytosol (more)
    Molecular Function protein kinase activity (more)
    GO Terms (all 29)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fyna-201 (1)    Ensembl 3215
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fyna
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(mbpa:mCherry,cafyna) mbpa fynamCherry Danio rerio 1 3
    Tg(mbpa:mCherry,fyna) mbpa fynamCherry Danio rerio 1 3
    MARKER RELATIONSHIPS
    fyna Contained in: [BAC] CH211-266G18 (1)
    fyna Encodes: [EST] IMAGE:6897140 (1)
    [cDNA] MGC:86720 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001007286 (1) 2534 nt
    Genomic GenBank:CU306817 176617 nt
    Select Tool
    Polypeptide UniProtKB:Q6EWH2 (1) 537 aa
    Sequence Information (all 18)
    ORTHOLOGY for fyna ( Chr: 17 )
    CITATIONS (42)