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Gene

bub1bb

ID
ZDB-GENE-030829-51
Name
BUB1 mitotic checkpoint serine/threonine kinase Bb
Symbol
bub1bb Nomenclature History
Previous Names
  • sb:cb730
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to enable protein kinase activity. Predicted to be involved in meiotic sister chromatid cohesion, centromeric and mitotic spindle assembly checkpoint signaling. Is expressed in hindbrain; optic tectum; pectoral fin musculature; proliferative region; and retina. Human ortholog(s) of this gene implicated in colorectal cancer and mosaic variegated aneuploidy syndrome 1. Orthologous to human BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2001
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With bub1bb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
colorectal cancer Alliance Colorectal cancer, somatic 114500
mosaic variegated aneuploidy syndrome 1 Alliance Mosaic variegated aneuploidy syndrome 1 257300
[Premature chromatid separation trait] 176430
Associated With bub1bb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013212 Mad3/Bub1 homology region 1
Family IPR015661 Mitotic spindle checkpoint protein Bub1/Mad3
Domain Details Per Protein
Protein Length Mad3/Bub1 homology region 1 Mitotic spindle checkpoint protein Bub1/Mad3
UniProtKB:A0A2R8PVS9 456
UniProtKB:E7F5T9 427
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations