ZFIN ID: ZDB-GENE-030828-2
Gene Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
Gene Symbol: hsd3b2
Sequence Ontology ID : SO:0000704

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Previous Names: hsd3b1, 3 beta hsd (1), cb723 (1), zgc:122972

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(Including Attributions)
Location: Chr: 20 Mapping Details/Browsers
Nomenclature History
Note: The name of this gene was changed because another gene was found to have very strong orthology with human HSD3B1. The current name of this gene, hsd3b2, reflects this gene's relationship to other hsd3b2 genes in fish and not its orthology to human HSD3B2
AUTOMATED DESCRIPTION
Exhibits 3-beta-hydroxy-delta5-steroid dehydrogenase activity; involved in embryonic morphogenesis and steroid biosynthetic process; orthologous to human HSD3B1 (hydroxy-delta-5-steroid  ...
GENE EXPRESSION
All Expression Data: 17 figures from 12 publications
Directly Submitted Expression Data: 3 figures (5 images) from Thisse et al., 2001 [cb723]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la021391Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: Fig. 8 from Lin et al., 2015
    Observed in:
    DISEASE ASSOCIATED WITH hsd3b2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hsd3b2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic morphogenesis (more)
    Molecular Function 3-beta-hydroxy-delta5-steroid dehydrogenase activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002225 (1)
  • InterPro:IPR036291 (1)
  • Pfam:PF01073 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA hsd3b2-201 (1) 1369
    hsd3b2-202 (1) 1258
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM hsd3b2 No data available
    MARKER RELATIONSHIPS
    hsd3b2Contained in: [BAC] DKEY-181I3 (1) (order this)
    hsd3b2Encodes: [EST] cb723 (1) (order this)
    [cDNA] MGC:111865 (1) (order this), MGC:122972 (order this), MGC:191949 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212797 (1) 1389bp
    Genomic GenBank:BX248418 (1) 152757bp
    Select Tool
    Polypeptide UniProtKB:F1QR80 (1) 374aa
    Sequence Clusters UniGene:119436 (1)
    Sequence Information (all 26)
    OTHER hsd3b2 GENE PAGES
  • Alliance (1)
  • Gene:373131 (1)
  • VEGA:OTTDARG00000006986 (1)
  • ORTHOLOGY for hsd3b2 (Chr: 20)
    CITATIONS (94)