ZFIN ID: ZDB-GENE-030826-3
Gene Name: CASP8 and FADD-like apoptosis regulator a
Gene Symbol: cflara    Nomenclature History

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Previous Names: cflar, Clarp1 (1), FLIP (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; and negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Predicted to localize to cytoplasm. Orthologous to human CFLAR (CASP8 and FADD like apoptosis regulator).
Genome Resources: Alliance (1),  Gene:373114 (1),  Ensembl(GRCz11):ENSDARG00000055966 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2599 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11641 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27804 Point Mutation Unknown Splice Site ENU
    sa27805 Point Mutation Unknown Splice Site ENU
    sa41869 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cflara N/A 1
    DISEASE ASSOCIATED WITH cflara HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cflara VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Cellular Component cytoplasm (more)
    Molecular Function cysteine-type endopeptidase activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cflara-201 (1)    Ensembl 2273
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-cflar monoclonal Rabbit WB Cell Signaling Technology, Inc.
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cflara No data available
    MARKER RELATIONSHIPS
    cflara Contained in: [BAC] DKEY-31D5 (1) (order this), DKEY-245J21 (1) (order this)
    cflara Encodes: [cDNA] MGC:136515 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001313772 (1)
    Genomic GenBank:BX323548 (1) 222367 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1R706 (1) 461 aa
    Sequence Information (all 19)
    ORTHOLOGY for cflara ( Chr: 11 )
    CITATIONS (28)