ZFIN ID: ZDB-GENE-030826-16
Gene Name: tropomyosin 3
Gene Symbol: tpm3    Nomenclature History

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Previous Names: cb674 (1), fa17b11, fb83b01, fk41e01, hm:zeh0298 (1), wu:fa17b11 (1), wu:fb83b01 (1), wu:fk41e01 (1), zeh0298, zgc:77592

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity. Involved in skeletal myofibril assembly. Predicted to localize to actin filament. Is expressed in several structures, including adaxial cell; alar plate midbrain region; axis; brain; and musculature system. Human ortholog(s) of this gene implicated in nemaline myopathy 1. Orthologous to human TPM3 (tropomyosin 3).
Genome Resources: Alliance (1),  Gene:373076 (1),  Ensembl(GRCz11):ENSDARG00000005162 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ct5aGt Transgenic Insertion Unknown Unknown DNA
la020572Tg Transgenic Insertion Unknown Unknown DNA
la020573Tg Transgenic Insertion Unknown Unknown DNA
la020574Tg Transgenic Insertion Unknown Unknown DNA
la020575Tg Transgenic Insertion Unknown Unknown DNA
sa9640 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16993 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23465 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36795 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tpm3
    1
    MO1-tpm3 N/A 1
    MO2-tpm3 N/A 1
    DISEASE ASSOCIATED WITH tpm3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital fiber-type disproportion Alliance Myopathy, congenital, with fiber-type disproportion 255310
    nemaline myopathy 1 Alliance CAP myopathy 1 609284
    Nemaline myopathy 1, autosomal dominant or recessive 609284
    DISEASE ASSOCIATED WITH tpm3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process skeletal myofibril assembly (more)
    Cellular Component actin filament (more)
    Molecular Function actin filament binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tpm3-201 (1)    Ensembl 2501
    tpm3-202 (1)    Ensembl 1496
    tpm3-203 (1)    Ensembl 386
    tpm3-204 (1)    Ensembl 3093
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tpm3 No data available
    MARKER RELATIONSHIPS
    tpm3 Contained in: [BAC] DKEY-240H12 (1) (order this)
    [Fosmid] CH1073-70F20 (1), CH1073-127A7 (1)
    tpm3 Contains: [SNP] rs3728969 (1), rs3728970 (1)
    tpm3 Encodes: [EST] cb674 (1) (order this), fa17b11, fb80c04 (1) (order this), fb83b01, fk41e01, zeh0298
    [cDNA] MGC:55539 (1), MGC:77592 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201492 (1) 2175 nt
    Genomic GenBank:CT573147 (1) 168801 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8Q650 (1) 284 aa
    Sequence Information (all 42)
    ORTHOLOGY for tpm3 ( Chr: 19 )
    CITATIONS (41)