ZFIN is now using GRCz12tu for Genomic Data
Gene
plaa
- ID
- ZDB-GENE-030826-13
- Name
- phospholipase A2-activating protein
- Symbol
- plaa Nomenclature History
- Previous Names
-
- cb623 (1)
- wu:fc45d08
- wu:fi33e06
- zgc:56568
- zgc:66193
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ubiquitin-modified protein reader activity. Predicted to be involved in several processes, including positive regulation of neuron migration; positive regulation of synaptic vesicle recycling; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in synapse. Predicted to be part of catalytic complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including eye; ovary; pectoral fin musculature; solid lens vesicle; and trigeminal placode. Human ortholog(s) of this gene implicated in microcephaly. Orthologous to human PLAA (phospholipase A2 activating protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb623 (9 images)
- IMAGE:7158753 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies | 617527 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR013535 | PUL domain |
| Domain | IPR015155 | PLAA family ubiquitin binding domain |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Homologous_superfamily | IPR038122 | PFU domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-like helical | PFU domain superfamily | PLAA family ubiquitin binding domain | PUL domain | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SXM2 | InterPro | 798 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers